4na2

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m (Protected "4na2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4na2| PDB=4na2 | SCENE= }}
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===Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate===
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{{ABSTRACT_PUBMED_24508341}}
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The entry 4na2 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PKSJ_BACSU PKSJ_BACSU]] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.<ref>PMID:16460000</ref> <ref>PMID:17234808</ref>
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Authors: Gay, D.C., Gay, G.R., Keatinge-Clay, A.T.
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==About this Structure==
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[[4na2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA2 OCA].
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Description: Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate
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==Reference==
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<ref group="xtra">PMID:024508341</ref><references group="xtra"/><references/>
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[[Category: Gay, D C.]]
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[[Category: Gay, G R.]]
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[[Category: Keatinge-Clay, A T.]]
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[[Category: Condensing enzyme fold]]
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[[Category: Transferase]]

Revision as of 17:35, 19 February 2014

Template:STRUCTURE 4na2

Contents

Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate

Template:ABSTRACT PUBMED 24508341

Function

[PKSJ_BACSU] Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.[1] [2]

About this Structure

4na2 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gay DC, Gay G, Axelrod AJ, Jenner M, Kohlhaas C, Kampa A, Oldham NJ, Piel J, Keatinge-Clay AT. A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase. Structure. 2014 Feb 4. pii: S0969-2126(14)00008-2. doi:, 10.1016/j.str.2013.12.016. PMID:24508341 doi:http://dx.doi.org/10.1016/j.str.2013.12.016
  1. ↑ Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 2006 Feb 14;45(6):1537-46. PMID:16460000 doi:http://dx.doi.org/10.1021/bi052333k
  2. ↑ Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1506-9. Epub 2007 Jan 18. PMID:17234808 doi:http://dx.doi.org/10.1073/pnas.0610503104

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