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3wn4

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3wn4| PDB=3wn4 | SCENE= }}
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===Crystal structure of human TLR8 in complex with DS-877===
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{{ABSTRACT_PUBMED_24474703}}
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The entry 3wn4 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
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Authors: Tanji, H., Ohto, U., Shimizu, T.
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==About this Structure==
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[[3wn4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WN4 OCA].
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Description: Crystal structure of human TLR8 in complex with DS-877
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==Reference==
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<ref group="xtra">PMID:024474703</ref><references group="xtra"/><references/>
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[[Category: Ohto, U.]]
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[[Category: Shimizu, T.]]
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[[Category: Tanji, H.]]
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[[Category: Antiviral-antitumor drug binding]]
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[[Category: Glycosylation]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Leucine rich repeat]]
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[[Category: Rna]]
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[[Category: Rna recognition]]
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[[Category: Ssrnar]]
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[[Category: Structure-based ligand design]]
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[[Category: Tlr8-specific agonist]]
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[[Category: Vaccine adjuvant]]

Revision as of 17:37, 19 February 2014

Template:STRUCTURE 3wn4

Contents

Crystal structure of human TLR8 in complex with DS-877

Template:ABSTRACT PUBMED 24474703

Function

[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]

About this Structure

3wn4 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kokatla HP, Sil D, Tanji H, Ohto U, Malladi SS, Fox LM, Shimizu T, David SA. Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists. ChemMedChem. 2014 Jan 28. doi: 10.1002/cmdc.201300573. PMID:24474703 doi:http://dx.doi.org/10.1002/cmdc.201300573
  1. ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200

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OCA

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