4ja7

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'''Unreleased structure'''
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{{STRUCTURE_4ja7| PDB=4ja7 | SCENE= }}
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===Rat PP5 co-crystallized with P5SA-2===
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The entry 4ja7 is ON HOLD until Feb 19 2015
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==Function==
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[[http://www.uniprot.org/uniprot/PPP5_RAT PPP5_RAT]] Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.<ref>PMID:11523989</ref> <ref>PMID:12176367</ref> <ref>PMID:15546861</ref> <ref>PMID:16892053</ref> <ref>PMID:16549782</ref>
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Authors: Haslbeck, V., Helmuth, M., Alte, F., Popowicz, G., Schmidt, W., Weiwad, M., Fischer, G., Gemmecker, G., Sattler, M., Striggow, F., Groll, M., Richter, K.
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==About this Structure==
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[[4ja7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA7 OCA].
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Description: Rat PP5 co-crystallized with P5SA-2
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Alte, F.]]
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[[Category: Fischer, G.]]
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[[Category: Gemmecker, G.]]
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[[Category: Groll, M.]]
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[[Category: Haslbeck, V.]]
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[[Category: Helmuth, M.]]
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[[Category: Popowicz, G.]]
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[[Category: Richter, K.]]
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[[Category: Sattler, M.]]
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[[Category: Schmidt, W.]]
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[[Category: Striggow, F.]]
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[[Category: Weiwad, M.]]
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[[Category: Activation]]
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[[Category: Hsp90]]
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[[Category: Hydrolase]]
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[[Category: Neurodegenerative disease]]
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[[Category: Pp5]]
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[[Category: Ser/thr-protein phosphatase domain]]
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[[Category: Tau-dephosphorylation]]
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[[Category: Tetratricopeptide repeat domain]]

Revision as of 17:47, 19 February 2014

Template:STRUCTURE 4ja7

Contents

Rat PP5 co-crystallized with P5SA-2

Function

[PPP5_RAT] Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.[1] [2] [3] [4] [5]

About this Structure

4ja7 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Kang H, Sayner SL, Gross KL, Russell LC, Chinkers M. Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation. Biochemistry. 2001 Sep 4;40(35):10485-90. PMID:11523989
  2. ↑ Yamaguchi Y, Katoh H, Mori K, Negishi M. Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Curr Biol. 2002 Aug 6;12(15):1353-8. PMID:12176367
  3. ↑ Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong CX. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. J Biol Chem. 2005 Jan 21;280(3):1790-6. Epub 2004 Nov 15. PMID:15546861 doi:http://dx.doi.org/10.1074/jbc.M410775200
  4. ↑ von Kriegsheim A, Pitt A, Grindlay GJ, Kolch W, Dhillon AS. Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5. Nat Cell Biol. 2006 Sep;8(9):1011-6. Epub 2006 Aug 6. PMID:16892053 doi:http://dx.doi.org/10.1038/ncb1465
  5. ↑ Gentile S, Darden T, Erxleben C, Romeo C, Russo A, Martin N, Rossie S, Armstrong DL. Rac GTPase signaling through the PP5 protein phosphatase. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5202-6. Epub 2006 Mar 20. PMID:16549782 doi:http://dx.doi.org/10.1073/pnas.0600080103

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