Cutinase

Cutinase (CUT) catalyzes the conversion of cutin to cutin monomers. Cutin is a main component of the plant cuticle. Polymeric cutin which is composed of hydroxyl and hydroxyepoxy fatty acids is found in the outer layer of plants. CUT is found in fungi and bacteria. CUT degrades the cutin enabling pathogens’ penetration into plant cells. Inhibition of CUT can prevent fungal plant infection. CUT is inhibited by organophosphates like E600 (diethyl-p-nitrophenyl phosphate)) and organophosphonates.

3D Structures of cutinase

Updated on 23-February-2014

1cus, 2cut, 1oxm, 1cex, 1agy, 3qpa – NhCUT – Nectria haematococca

1ffa, 1ffb, 1ffc, 1ffd, 1ffe, 1cua, 1cub, 1cuc, 1cud, 1cue, 1cuf, 1cug, 1cuh, 1cui, 1cuj, 1cuu, 1cuv, 1cuw, 1cux, 1cuy, 1cuz, 1xza, 1xzb, 1xzc, 1xzd, 1xze, 1xzf, 1xzg, 1xzh, 1xzi, 1xzj – NhCUT (mutant)
3dcn – GcCUT – Glomerella cingulata
3gbs – CUT – Aspergillus oryzae
3esc – CUT – Fusarium solani

Cutinase complex with inhibitor

1xzl – NhCUT + hexylphosphonate ethyl ester

1xzk – NhCUT + di-isopropyl phosphate
1xzm – NhCUT + undecyl chloro phosphonate ester
3dd5 – GcCUT + E600
3dea – GcCUT + PETFP
3ef3, 3esa, 3esb, 3eac, 3esd – NhCUT + Pt inhibitor
3qpc – NhCUT + paraoxon
3qpd – NhCUT + phosphoserine