C-X-C motif chemokine
From Proteopedia
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'''C-X-C motif chemokine''' (CXCL) are small chemokines.<br /> | '''C-X-C motif chemokine''' (CXCL) are small chemokines.<br /> | ||
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| + | • '''CXCL2''' or '''MIP-2''' or '''imacrophage inflammatory protein 2''' acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.<br /> | ||
• '''CXCL10''' or '''IP-10''' or '''interferon γ-induced protein 10''' acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.<br /> | • '''CXCL10''' or '''IP-10''' or '''interferon γ-induced protein 10''' acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.<br /> | ||
• '''CXCL11''' or '''IP-9''' or '''interferon γ-induced protein 9''' acts as chemotactic for activated T cells.<br /> | • '''CXCL11''' or '''IP-9''' or '''interferon γ-induced protein 9''' acts as chemotactic for activated T cells.<br /> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | ===CXCL2=== | ||
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| + | [[3n52]] – mCXCL – mouse<br /> | ||
| + | [[1mi2]] – mCXCL – NMR<br /> | ||
===CXCL10=== | ===CXCL10=== | ||
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[[1lv9]] – hCXCL – human – NMR<br /> | [[1lv9]] – hCXCL – human – NMR<br /> | ||
[[1o7z]], [[1o7y]], [[1o80]] – hCXCL<br /> | [[1o7z]], [[1o7y]], [[1o80]] – hCXCL<br /> | ||
| - | [[2r3z]] – | + | [[2r3z]] – mCXCL <br /> |
===CXCL11=== | ===CXCL11=== | ||
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[[2j7z]] - hSDF1α residues 22-89<br /> | [[2j7z]] - hSDF1α residues 22-89<br /> | ||
[[2k03]], [[2k04]], [[2k05]] - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)<br /> | [[2k03]], [[2k04]], [[2k05]] - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)<br /> | ||
| + | [[4lmq]] - hSDF1α + immunoghlobulin heavy chain<br /> | ||
===CXCL14=== | ===CXCL14=== | ||
Revision as of 09:29, 24 February 2014
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| CXCL12α dimer complex with sulfate, 1qg7 | |||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
C-X-C motif chemokine (CXCL) are small chemokines.
• CXCL2 or MIP-2 or imacrophage inflammatory protein 2 acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.
• CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.
• CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells.
• CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis.
• CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis.
Contents |
3D Structures of C-X-C motif chemokine
Updated on 24-February-2014
CXCL2
3n52 – mCXCL – mouse
1mi2 – mCXCL – NMR
CXCL10
1lv9 – hCXCL – human – NMR
1o7z, 1o7y, 1o80 – hCXCL
2r3z – mCXCL
CXCL11
1rjt – hCXCL
CXCL12
3D Structures of Stromal Derived Factor 1
Updated on 24-February-2014
2kec, 2ked, 2kee, 2sdf, 1sdf, 1vmc - hSDF1α – NMR - human
1qg7, 3hp3 - hSDF1α
2k0l, 2k01, 2kol – hSDF1α (mutant) – NMR
1a15, 3gv3 - hSDF1α (mutant)
2nwg - hSDF1α+heparin
2j7z - hSDF1α residues 22-89
2k03, 2k04, 2k05 - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)
4lmq - hSDF1α + immunoghlobulin heavy chain
CXCL14
2hdl – hCXCL – NMR
