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Defensin
From Proteopedia
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[[3gny]], [[3go0]], [[3hj2]] - hDEFA HNP-1<BR /> | [[3gny]], [[3go0]], [[3hj2]] - hDEFA HNP-1<BR /> | ||
[[2kht]] - hDEFA HNP-1 - NMR<BR /> | [[2kht]] - hDEFA HNP-1 - NMR<BR /> | ||
| - | [[2pm1]], [[2pm4]], [[2pm5]], [[3hjd]], [[3h6c]], [[3lo1]], [[3lo2]], [[3lo4]], [[3lo6]], [[3lo8]], [[3loe]], [[3lvx]], [[4du0]] - hDEFA HNP-1 (mutant) <BR /> | + | [[2pm1]], [[2pm4]], [[2pm5]], [[3hjd]], [[3h6c]], [[3lo1]], [[3lo2]], [[3lo4]], [[3lo6]], [[3lo8]], [[3loe]], [[3lvx]], [[4du0]], [[4lb1]], [[4lb7]], [[4lbb]], [[4lbf]] - hDEFA HNP-1 (mutant) <BR /> |
[[1zmm]] – hDEFA4 <BR /> | [[1zmm]] – hDEFA4 <BR /> | ||
| + | [[2lew]] – mDEFA4 (mutant) – mouse – NMR<br /> | ||
| + | [[2ley]] – mDEFA4 – NMR<br /> | ||
[[1zmp]] – hDEFA5<BR /> | [[1zmp]] – hDEFA5<BR /> | ||
| + | [[2lxz]] – hDEFA5 – NMR<br /> | ||
[[3i5w]], [[4e82]], [[4e83]], [[4e86]] – hDEFA5 (mutant) <BR /> | [[3i5w]], [[4e82]], [[4e83]], [[4e86]] – hDEFA5 (mutant) <BR /> | ||
[[1zmq]] – hDEFA6<BR /> | [[1zmq]] – hDEFA6<BR /> | ||
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[[1iju]], [[1ijv]] – hDEFB1<BR /> | [[1iju]], [[1ijv]] – hDEFB1<BR /> | ||
| - | [[2nlb]], [[2nld]], [[2nle]], [[2nlf]], [[2nlg]], [[2nlh]], [[2nlp]], [[2nlq]], [[2nls]], [[2plz]] - hDEFB1 (mutant) <BR /> | + | [[2nlb]], [[2nld]], [[2nle]], [[2nlf]], [[2nlg]], [[2nlh]], [[2nlp]], [[2nlq]], [[2nls]], [[2plz]], [[2lwl]], [[2nlc]] - hDEFB1 (mutant) <BR /> |
[[1e4s]], [[1kj5]] – hDEFB1 – NMR<BR /> | [[1e4s]], [[1kj5]] – hDEFB1 – NMR<BR /> | ||
[[1fd3]], [[1fd4]] – hDEFB2 <BR /> | [[1fd3]], [[1fd4]] – hDEFB2 <BR /> | ||
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[[2lg6]] - cDEFB2 (mutant) – NMR<BR /> | [[2lg6]] - cDEFB2 (mutant) – NMR<BR /> | ||
[[1kj6]] – hDEFB3 – NMR<BR /> | [[1kj6]] – hDEFB3 – NMR<BR /> | ||
| - | [[1e4t]] – mDEFB7 | + | [[1e4t]] – mDEFB7 – NMR<BR /> |
[[1e4r]] - mDEFB8 – NMR<BR /> | [[1e4r]] - mDEFB8 – NMR<BR /> | ||
[[1bnb]] – DEFB12 – bovine – NMR<BR /> | [[1bnb]] – DEFB12 – bovine – NMR<BR /> | ||
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[[3psm]] – DEF – Potato bean<BR /> | [[3psm]] – DEF – Potato bean<BR /> | ||
[[2ksk]] – DEF5 – Sugarcane - NMR<BR /> | [[2ksk]] – DEF5 – Sugarcane - NMR<BR /> | ||
| + | [[2lj7]] – DEF – lentil – NMR<br /> | ||
| + | [[2lr3]] – DEF – barrel medic – NMR<br /> | ||
| + | |||
| + | [[Category:Topic Page]] | ||
Revision as of 11:44, 24 February 2014
Defensins (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients. There is increase in α-DEF in chronic inflammations and several cancers. For details on plant DEF see Plant defensin.
Contents |
3D structures of defensin
α-defensin
1ica – DEFA – Protophormia terraenovae
1ews – DEFA RK-1 – rabbit – NMR
2k1i - RmDEFA – Rhesus macaque - NMR
1zmh, 1zmi, 1zmk - hDEFA HNP-2 (mutant) – human
3gny, 3go0, 3hj2 - hDEFA HNP-1
2kht - hDEFA HNP-1 - NMR
2pm1, 2pm4, 2pm5, 3hjd, 3h6c, 3lo1, 3lo2, 3lo4, 3lo6, 3lo8, 3loe, 3lvx, 4du0, 4lb1, 4lb7, 4lbb, 4lbf - hDEFA HNP-1 (mutant)
1zmm – hDEFA4
2lew – mDEFA4 (mutant) – mouse – NMR
2ley – mDEFA4 – NMR
1zmp – hDEFA5
2lxz – hDEFA5 – NMR
3i5w, 4e82, 4e83, 4e86 – hDEFA5 (mutant)
1zmq – hDEFA6
3qte – hDEFA6 (mutant)
β-defensin
1iju, 1ijv – hDEFB1
2nlb, 2nld, 2nle, 2nlf, 2nlg, 2nlh, 2nlp, 2nlq, 2nls, 2plz, 2lwl, 2nlc - hDEFB1 (mutant)
1e4s, 1kj5 – hDEFB1 – NMR
1fd3, 1fd4 – hDEFB2
1fqq, 1e4q - hDEFB2 – NMR
2lg5 - cDEFB2 – chicken – NMR
2lg6 - cDEFB2 (mutant) – NMR
1kj6 – hDEFB3 – NMR
1e4t – mDEFB7 – NMR
1e4r - mDEFB8 – NMR
1bnb – DEFB12 – bovine – NMR
ϑ-defensin
1hvz – RmDEF1 – NMR
Other defensins
1dfn – hDEF HNP-3
1fjn – DEF MGD-1 – Mediterranean mussel
1mr4 – tDEF NAD1 – tobacco – NMR
4aaz, 4ab0 - tDEF NAD1
1ozz – AdDEF ARD1 – Archaeoprepona demophon – NMR
1p00, 1p0a - AdDEF ARD1 (mutant) – NMR
1ti5 - VrDEF – Vigna radiata – NMR
2gl1 – VrDEF2
2b68 - DEF – Pacific oyster – NMR
2b5b - DEF – Loggerhead turtle – NMR
2e3e, 2e3f, 2e3g, 2ny8, 2ny9, 2nz3 - DEF (mutant) – Anopheles – NMR
2rng - DEF – Horseshoe crab – NMR
3psm – DEF – Potato bean
2ksk – DEF5 – Sugarcane - NMR
2lj7 – DEF – lentil – NMR
2lr3 – DEF – barrel medic – NMR
