3ncm
From Proteopedia
(New page: 200px<br /><applet load="3ncm" size="450" color="white" frame="true" align="right" spinBox="true" caption="3ncm" /> '''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR...) |
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| - | [[Image:3ncm.gif|left|200px]]<br /><applet load="3ncm" size=" | + | [[Image:3ncm.gif|left|200px]]<br /><applet load="3ncm" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="3ncm" /> | caption="3ncm" /> | ||
'''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES'''<br /> | '''NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure in solution of the second Ig-module fragment of residues | + | The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion. |
==About this Structure== | ==About this Structure== | ||
| - | 3NCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http:// | + | 3NCM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Berezin, V.]] | [[Category: Berezin, V.]] | ||
[[Category: Bock, E.]] | [[Category: Bock, E.]] | ||
| - | [[Category: Jensen, P | + | [[Category: Jensen, P H.]] |
| - | [[Category: Poulsen, F | + | [[Category: Poulsen, F M.]] |
[[Category: Soroka, V.]] | [[Category: Soroka, V.]] | ||
| - | [[Category: Thomsen, N | + | [[Category: Thomsen, N K.]] |
[[Category: cell adhesion]] | [[Category: cell adhesion]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
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[[Category: neural adhesion molecule]] | [[Category: neural adhesion molecule]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:10:25 2008'' |
Revision as of 17:10, 21 February 2008
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NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES
Overview
The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
About this Structure
3NCM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion., Jensen PH, Soroka V, Thomsen NK, Ralets I, Berezin V, Bock E, Poulsen FM, Nat Struct Biol. 1999 May;6(5):486-93. PMID:10331878
Page seeded by OCA on Thu Feb 21 19:10:25 2008
