This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Interleukin
From Proteopedia
| Line 2: | Line 2: | ||
'''Interleukin''' (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.<br /> | '''Interleukin''' (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.<br /> | ||
| - | * IL-1 is a group of 11 cytokines which regulate immune and inflammatory response.<br /> | + | * IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See [[Interleukin-1 beta]].<br /> |
* IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | * IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | ||
* IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.<br /> | * IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.<br /> | ||
Revision as of 11:16, 25 February 2014
Template:STRUCTURE 2nvh
Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.
- IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
- IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
- IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
- IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
- IL-5 stimulates B cell growth and increases immunoglobulin secretion.
- IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
- IL-7 is a cytokine important for B and T cells development.
- IL-8 induces chemotaxis and phagocytosis.
- IL-10 see Interleukin-10.
- IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
- IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
- IL-15 see Interleukin-15.
- IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
- IL-17 recruits monocytes and neutrophils to the site of inflammation.
- IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
- IL-19 induces activation of the signal transducer and activator of STAT3.
- IL-21 has potent effect on natural killer cells.
- IL-22 stimulates inflammatory responses like S100 and defensin.
- IL-23 induces activation of the signal transducer and activator of STAT4.
- IL-28 has a role in the immune defense against viruses.
- IL-29 similar to IL-28.
- IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
- IL-34 increases growth or survival of monocytes.
3D structures of interleukin
Updated on 25-February-2014
IL-1 α
2ila - hIL-1 α - human
2kki - hIL-1 α residues 121-271
2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR
IL-1 β
2wry - cIL-1 β – chicken
3nj5 – cIL-1 β (mutant)
2nvh, 9ilb, 1iob, 5i1b, 2i1b, 4i1b, 1i1b - hIL-1 β
1tp0, 1t4q, 1too, 1twe, 1twm, 1s0l, 1l2h, 1hib, 21bi, 31bi, 41bi - hIL-1 β (mutant)
6i1b, 7i1b - hIL-1 β - NMR
3ltq - hIL-1 β residues 117-269
3pok - hIL-1 β residues 117-269 (mutant)
1itb - hIL-1 β + IL-1 receptor 1 extracellular domain
3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein
4g6j, 4g6m - hIL-1 β + antibody
2kh2 - hIL-1 β + SCFV - NMR
1md6 – mIL-1F5 – mouse
2mib, 8i1b - mIL-1 β
IL-2 (T-cell growth factor)
1m47, 1m4c, 3ink – hIL-2
3qb1 - hIL-2 (mutant)
1irl – hIL-2 (mutant) - NMR
2erj, 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ
1z92 - hIL-2 + IL-2 receptor α
1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor
1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor
IL-3
1jli – hIL-3 (mutant) – NMR
2l3o – mIL-3 residues 33-156 (mutant) - NMR
IL-4
2b8u, 1hik, 2int, 1rcb – hIL-4
2cyk, 1cyl, 1itm, 1bbn, 1bcn, 1iti, 1itl – hIL-4 - NMR
2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 1hzi, 1hij - hIL-4 (mutant)
1iar - hIL-4 + IL-4 receptor α (mutant)
3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ
3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α
IL-5
IL-6
1alu – hIL-6
2l3y - mIL-6 residues 27-211 - NMR
1il6, 2il6 – hIL-6 - NMR
1p9m - hIL-6 + IL-6 receptor α and β
1i16 – IL-6 + IL-6 receptor β - Herpesvirus 8
IL-7
3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain
IL-8
3il8 – hIL-8
1il8, 2il8 – hIL-8]- NMR
1qe6, 1icw – hIL-8 (mutant)
1ikl, 1ikm - hIL-8 (mutant) - NMR
1rod - hIL-8/melanoma growth stimulating protein – NMR
1ilp, 1ilq - hIL-8 + IL-8 receptor peptide
IL-10
2h24, 1inr, 2ilk, 1ilk – hIL-10
1j7v – hIL-10 + IL-10 receptor α (mutant)
1y6k - hIL-10 residues 19-178 + IL-10 receptor α
IL-10 viral
1vlk - hvIL-10 residues 26-170 - human herpesvirus 4
1y6m - hvIL-10 residues 26-170 + IL-10 receptor α
1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α
1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5
1lk3 - hvIL-10 residues 26-175 + antibody
IL-12
1f45 - hIL-12 α and β (mutant)
1f42 - hIL-12 β P40 domain
3hmx - hIL-12 α and β+ antibody
3qwr - hIL-12 β + hIL- 23 α + adnectin
IL-13
1ijz, 1ik0 – hIL-13 – NMR
1ga3 - hIL-13 residues 21-132 - NMR
3l5w, 3l5x, 3l5y, 3g6d, 4i77 - hIL-13 residues 35-146 + antibody
3lb6 - hIL-13 + IL-13 receptor α2
3bpo - hIL-13 + IL-4 receptor α + IL-13 receptor α
IL-15
2xqb – hIL-15 + antibody
2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α
IL-16
1i16 – hIL-16 - NMR
1x6d – hIL-16 PDZ domain – NMR
IL-17
4hr9 - hIL-17A (mutant)
2vxs - hIL-17A residues 20-255 + antibody
1jpy – hIL-17F
3jvf - hIL-17F + IL-17 receptor α
IL-18 (Interferon-γ inducing factor)
1j0s – hIL-18 - NMR
4hjj - hIL-18 + antibody
2vxt - hIL-18 (mutant) + antibody
3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein
4eee, 4ekx - hIL-18 (mutant) + 14L protein
IL-19
1n1f – hIL-19
IL-21
2oqp– hIL-21 – NMR
IL-22
1ykb, 1m4r – hIL-22
3g9v - hIL-22 residues 29-179 + IL-22 receptor α2
3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1
3q1s - hIL-22 residues 29-179 (mutant) + antibody
IL-23
3d87 - hIL-23 α
3d85 - hIL-23 α + antibody
3duh - hIL-23 α + hIL-12 β
IL-28
3hhc – hIL-28B
IL-29
3og4, 3og6 – hIL-29 + IL-28 receptor α
IL-33
2kll - hIL-33 residues 110-270 - NMR
IL-34
4dkc - hIL-34
4exn - mIL-34
4dkd - hIL-34 active core + macrophage colony-stimulating factor 1 receptor
4exp - mIL-34 active core + macrophage colony-stimulating factor 1 receptor
4dke, 4dkf - hIL-34 active core + antibody
