Dual specificity protein kinase
From Proteopedia
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===TTK=== | ===TTK=== | ||
| - | [[3cek]], [[3dbq]] – hTTK kinase domain | + | [[3cek]], [[3dbq]] – hTTK kinase domain<br /> |
| - | + | [[4b94]], [[4h7x]], [[4h7y]] - hTTK TPR domain<br /> | |
[[3gfw]] - hTTK kinase domain + pyrolo-pyridin ligand | [[3gfw]] - hTTK kinase domain + pyrolo-pyridin ligand | ||
[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand | [[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand | ||
| - | [[2x9e]] - hTTK kinase domain + inhibitor | + | [[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]] - hTTK kinase domain + inhibitor |
[[2zmc]] - hTTK catalytic domain | [[2zmc]] - hTTK catalytic domain | ||
Revision as of 08:54, 3 March 2014
Dual specificity protein kinases are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing.
3D structures of dual specificity protein kinase
Updated on 03-March-2014
CLK1
1z57 – hCLK1 kinase domain + himenialdizine – human
2vag - hCLK1 kinase domain + indole inhibitor
CLK2
3nr9 – hCLK2 kinase domain
CLK3
2eu9 – hCLK3
2exe – hCLK3 kinase domain, phosphorylated
2wu6, 2wu7 – hCLK3 kinase domain + inhibitor
3raw - hCLK3 kinase domain + leucettine
TTK
3cek, 3dbq – hTTK kinase domain
4b94, 4h7x, 4h7y - hTTK TPR domain
3gfw - hTTK kinase domain + pyrolo-pyridin ligand
3h9f - hTTK kinase domain + pyrimidino-diazepin ligand
2x9e, 3vqu, 3w1f, 4bhz, 4bi0, 4bi1, 4bi2, 4c4e, 4c4f, 4c4g, 4c4h, 4c4i, 4c4j - hTTK kinase domain + inhibitor
2zmc - hTTK catalytic domain
2zmd - hTTK catalytic domain (mutant) + inhibitor
3hmn - hTTK catalytic domain + ATP
3hmo - hTTK catalytic domain + staurosporine
3hmp - hTTK catalytic domain + quinazolin ligand
