2yka

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[[Image:2yka.jpg|left|200px]]
 
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{{STRUCTURE_2yka| PDB=2yka | SCENE= }}
{{STRUCTURE_2yka| PDB=2yka | SCENE= }}
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===RRM domain of mRNA export adaptor REF2-I bound to HVS ORF57 peptide===
===RRM domain of mRNA export adaptor REF2-I bound to HVS ORF57 peptide===
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{{ABSTRACT_PUBMED_24550725}}
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==Function==
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[[http://www.uniprot.org/uniprot/ALRF2_MOUSE ALRF2_MOUSE]] Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity.<ref>PMID:10786854</ref> <ref>PMID:11158589</ref> <ref>PMID:18364396</ref> [[http://www.uniprot.org/uniprot/ICP27_SHV21 ICP27_SHV21]] Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins. Probably acts as a viral splicing factor that regulates viral RNA splicing. Functions as a multifunctional regulator of the expression of viral lytic genes (By similarity).
==About this Structure==
==About this Structure==
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[[2yka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Saimiriine_herpesvirus_2 Saimiriine herpesvirus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKA OCA].
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[[2yka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpesvirus_saimiri Herpesvirus saimiri] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKA OCA].
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[[Category: Mus musculus]]
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[[Category: Saimiriine herpesvirus 2]]
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==Reference==
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<ref group="xtra">PMID:024550725</ref><references group="xtra"/><references/>
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[[Category: Herpesvirus saimiri]]
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[[Category: Lk3 transgenic mice]]
[[Category: Golovanov, A P.]]
[[Category: Golovanov, A P.]]
[[Category: Hautbergue, G M.]]
[[Category: Hautbergue, G M.]]

Revision as of 14:59, 3 March 2014

Template:STRUCTURE 2yka

Contents

RRM domain of mRNA export adaptor REF2-I bound to HVS ORF57 peptide

Template:ABSTRACT PUBMED 24550725

Function

[ALRF2_MOUSE] Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity.[1] [2] [3] [ICP27_SHV21] Early protein that promotes the accumulation and nuclear export of viral intronless RNA transcripts by interacting with mRNAs and cellular export proteins. Probably acts as a viral splicing factor that regulates viral RNA splicing. Functions as a multifunctional regulator of the expression of viral lytic genes (By similarity).

About this Structure

2yka is a 2 chain structure with sequence from Herpesvirus saimiri and Lk3 transgenic mice. Full experimental information is available from OCA.

Reference

  • Tunnicliffe RB, Hautbergue GM, Wilson SA, Kalra P, Golovanov AP. Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF. PLoS Pathog. 2014 Feb 13;10(2):e1003907. doi: 10.1371/journal.ppat.1003907., eCollection 2014 Feb. PMID:24550725 doi:http://dx.doi.org/10.1371/journal.ppat.1003907
  1. ↑ Stutz F, Bachi A, Doerks T, Braun IC, Seraphin B, Wilm M, Bork P, Izaurralde E. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA. 2000 Apr;6(4):638-50. PMID:10786854
  2. ↑ Rodrigues JP, Rode M, Gatfield D, Blencowe BJ, Carmo-Fonseca M, Izaurralde E. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1030-5. Epub 2001 Jan 23. PMID:11158589 doi:http://dx.doi.org/10.1073/pnas.031586198
  3. ↑ Hautbergue GM, Hung ML, Golovanov AP, Lian LY, Wilson SA. Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5154-9. doi:, 10.1073/pnas.0709167105. Epub 2008 Mar 25. PMID:18364396 doi:http://dx.doi.org/10.1073/pnas.0709167105

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