4bwl

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{{STRUCTURE_4bwl| PDB=4bwl | SCENE= }}
{{STRUCTURE_4bwl| PDB=4bwl | SCENE= }}
===Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid===
===Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid===
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{{ABSTRACT_PUBMED_24521460}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
[[4bwl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWL OCA].
[[4bwl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWL OCA].
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==Reference==
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<ref group="xtra">PMID:024521460</ref><references group="xtra"/><references/>
[[Category: N-acetylneuraminate lyase]]
[[Category: N-acetylneuraminate lyase]]
[[Category: Berry, A.]]
[[Category: Berry, A.]]

Revision as of 15:46, 3 March 2014

Template:STRUCTURE 4bwl

Contents

Structure of the Y137A mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate, N-acetyl-D-mannosamine and N- acetylneuraminic acid

Template:ABSTRACT PUBMED 24521460

Function

[NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]

About this Structure

4bwl is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Daniels AD, Campeotto I, van der Kamp MW, Bolt AH, Trinh CH, Phillips SE, Pearson AR, Nelson A, Mulholland AJ, Berry A. Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis. ACS Chem Biol. 2014 Feb 21. PMID:24521460 doi:http://dx.doi.org/10.1021/cb500067z

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