402d
From Proteopedia
(New page: 200px<br /><applet load="402d" size="350" color="white" frame="true" align="right" spinBox="true" caption="402d, resolution 2.300Å" /> '''5'-R(*CP*GP*CP*CP*A...) |
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==Overview== | ==Overview== | ||
| - | The crystal structure of the RNA octamer 5'-CGC(CA)GCG-3' has been | + | The crystal structure of the RNA octamer 5'-CGC(CA)GCG-3' has been determined from X-ray diffraction data to 2.3 A resolution. In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit. Tandem non-Watson-Crick C-A and A-C base pairs comprise an internal loop in the middle of the duplex, which is incorporated with little distortion of the A-form double helix. From the geometry of the C-A base pairs, it is inferred that the adenosine imino group is protonated and donates a hydrogen bond to the carbonyl group of the cytosine. The wobble geometry of the C-A+ base pairs is very similar to that of the common U-G non-Watson-Crick pair. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Carter, R.]] | [[Category: Carter, R.]] | ||
| - | [[Category: Chi, Y | + | [[Category: Chi, Y I.]] |
| - | [[Category: Holbrook, E | + | [[Category: Holbrook, E L.]] |
| - | [[Category: Holbrook, S | + | [[Category: Holbrook, S R.]] |
| - | [[Category: Hung, L | + | [[Category: Hung, L W.]] |
| - | [[Category: Jang, S | + | [[Category: Jang, S B.]] |
[[Category: rna double helix]] | [[Category: rna double helix]] | ||
[[Category: rna with tandem c-a+ base pair]] | [[Category: rna with tandem c-a+ base pair]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:52 2008'' |
Revision as of 17:11, 21 February 2008
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5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'
Overview
The crystal structure of the RNA octamer 5'-CGC(CA)GCG-3' has been determined from X-ray diffraction data to 2.3 A resolution. In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit. Tandem non-Watson-Crick C-A and A-C base pairs comprise an internal loop in the middle of the duplex, which is incorporated with little distortion of the A-form double helix. From the geometry of the C-A base pairs, it is inferred that the adenosine imino group is protonated and donates a hydrogen bond to the carbonyl group of the cytosine. The wobble geometry of the C-A+ base pairs is very similar to that of the common U-G non-Watson-Crick pair.
About this Structure
402D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of an RNA internal loop consisting of tandem C-A+ base pairs., Jang SB, Hung LW, Chi YI, Holbrook EL, Carter RJ, Holbrook SR, Biochemistry. 1998 Aug 25;37(34):11726-31. PMID:9718295
Page seeded by OCA on Thu Feb 21 19:11:52 2008
