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4i1t
From Proteopedia
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| - | + | {{STRUCTURE_4i1t| PDB=4i1t | SCENE= }} | |
| + | ===Crystal structure of the cap-snatching endonuclease from Pichinde virus=== | ||
| - | The | + | ==Function== |
| + | [[http://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836] | ||
| - | + | ==About this Structure== | |
| - | + | [[4i1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA]. | |
| - | + | [[Category: RNA-directed RNA polymerase]] | |
| + | [[Category: Bussetta, C.]] | ||
| + | [[Category: Choi, K H.]] | ||
| + | [[Category: Arenavirus]] | ||
| + | [[Category: Cap-snatching]] | ||
| + | [[Category: Cap-snatching rna endonuclease]] | ||
| + | [[Category: Endonuclease]] | ||
| + | [[Category: L protein]] | ||
| + | [[Category: Pichinde virus]] | ||
| + | [[Category: Rna-dependent rna polymerase]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Viral transcription]] | ||
Revision as of 18:20, 3 March 2014
Crystal structure of the cap-snatching endonuclease from Pichinde virus
Function
[Q915A5_PIARV] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]
About this Structure
4i1t is a 1 chain structure. Full crystallographic information is available from OCA.
