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4jzi

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'''Unreleased structure'''
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{{STRUCTURE_4jzi| PDB=4jzi | SCENE= }}
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===Crystal Structure of Matriptase in complex with Inhibitor".===
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The entry 4jzi is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
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Authors: Subramanya, H.S., Chandra, R.B., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S.
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==Function==
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[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
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Description: Crystal Structure of Matriptase in complex with Inhibitor".
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==About this Structure==
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[[4jzi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZI OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Matriptase]]
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[[Category: Ashok, K N.]]
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[[Category: Chakshusmathi, G.]]
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[[Category: Chandra, R B.]]
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[[Category: Ramesh, K S.]]
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[[Category: Subramanya, H S.]]
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[[Category: Complex structure]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Matriptase]]

Revision as of 18:21, 3 March 2014

Template:STRUCTURE 4jzi

Contents

Crystal Structure of Matriptase in complex with Inhibitor".

Disease

[ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.[1]

Function

[ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.

About this Structure

4jzi is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Basel-Vanagaite L, Attia R, Ishida-Yamamoto A, Rainshtein L, Ben Amitai D, Lurie R, Pasmanik-Chor M, Indelman M, Zvulunov A, Saban S, Magal N, Sprecher E, Shohat M. Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet. 2007 Mar;80(3):467-77. Epub 2007 Jan 23. PMID:17273967 doi:S0002-9297(07)60095-0

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OCA

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