4nn2

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-	'''Unreleased structure'''	+	{{STRUCTURE_4nn2| PDB=4nn2 | SCENE= }}
		+	===Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6===
-	The entry 4nn2 is ON HOLD until Nov 16 2015	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PHF6_HUMAN PHF6_HUMAN]] Borjeson-Forssman-Lehmann syndrome. The disease is caused by mutations affecting the gene represented in this entry.
-	Authors: Liu, Z., Li,F., Zhang, J., Mei,Y., Wu, J., Shi,Y.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PHF6_HUMAN PHF6_HUMAN]] Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.<ref>PMID:23229552</ref>
-	Description: Protein Crystal Structure	+	==About this Structure==
		+	[[4nn2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN2 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Li,F.]]
		+	[[Category: Liu, Z.]]
		+	[[Category: Mei,Y.]]
		+	[[Category: Shi,Y.]]
		+	[[Category: Wu, J.]]
		+	[[Category: Zhang, J.]]
		+	[[Category: Transcription]]
		+	[[Category: Zinc finger]]

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Revision as of 18:26, 3 March 2014

Template:STRUCTURE 4nn2

Contents 1 Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6 2 Disease 3 Function 4 About this Structure 5 Reference

Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6

Disease

[PHF6_HUMAN] Borjeson-Forssman-Lehmann syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[PHF6_HUMAN] Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.^[1]

About this Structure

4nn2 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 1;288(5):3174-83. doi: 10.1074/jbc.M112.414839. Epub 2012, Dec 10. PMID:23229552 doi:http://dx.doi.org/10.1074/jbc.M112.414839