This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4ogj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4ogj" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4ogj| PDB=4ogj | SCENE= }}
 +
===Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348===
-
The entry 4ogj is ON HOLD
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-
Authors: Filippakopoulos, P., Picaud, S., Jose, B., Martin, S., Fedorov, O., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+
==Function==
 +
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348
+
==About this Structure==
 +
[[4ogj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGJ OCA].
 +
 
 +
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Arrowsmith, C H.]]
 +
[[Category: Bountra, C.]]
 +
[[Category: Delft, F Von.]]
 +
[[Category: Edwards, A M.]]
 +
[[Category: Fedorov, O.]]
 +
[[Category: Filippakopoulos, P.]]
 +
[[Category: Jose, B.]]
 +
[[Category: Knapp, S.]]
 +
[[Category: Martin, S.]]
 +
[[Category: Picaud, S.]]
 +
[[Category: SGC, Structural Genomics Consortium.]]
 +
[[Category: Bromodomain]]
 +
[[Category: Bromodomain containing protein 4]]
 +
[[Category: Flt3 kinase inhibitor]]
 +
[[Category: Jak2 kinase inhibitor]]
 +
[[Category: Sgc]]
 +
[[Category: Structural genomic]]
 +
[[Category: Structural genomics consortium]]
 +
[[Category: Transcription-inhibitor complex]]

Revision as of 18:28, 3 March 2014

Template:STRUCTURE 4ogj

Contents

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor TG-101348

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4ogj is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ogj"
Personal tools