4oqe

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m (Protected "4oqe" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4oqe| PDB=4oqe | SCENE= }}
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===Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe===
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The entry 4oqe is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TYLM1_STRFR TYLM1_STRFR]] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>
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Authors: thoden, J.B., holden, H.M.
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==About this Structure==
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[[4oqe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQE OCA].
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Description: Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe
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==Reference==
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<references group="xtra"/><references/>
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[[Category: DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase]]
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[[Category: Holden, H M.]]
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[[Category: Thoden, J B.]]
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[[Category: N-methyltransferase]]
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[[Category: S-adenosylmethionine]]
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[[Category: Sam methyltransferase]]
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[[Category: Transferase]]

Revision as of 18:29, 3 March 2014

Template:STRUCTURE 4oqe

Contents

Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe

Function

[TYLM1_STRFR] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.[1] [2] [3]

About this Structure

4oqe is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Gandecha AR, Large SL, Cundliffe E. Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. Gene. 1997 Jan 15;184(2):197-203. PMID:9031628
  2. ↑ Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW. Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine. Biochemistry. 2002 Jul 23;41(29):9165-83. PMID:12119032
  3. ↑ Carney AE, Holden HM. Molecular Architecture of TylM1 from Streptomyces fradiae: an N,N-Dimethyltransferase Involved in the Production of dTDP-D-Mycaminose. Biochemistry. 2010 Dec 13. PMID:21142177 doi:10.1021/bi101733y

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