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Ephrin receptor

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===Ephrin A1 receptor===
===Ephrin A1 receptor===
[[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
[[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
 +
[[3hil]] - hEPH A1 SAM<br />
[[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
[[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
[[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
[[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
Line 20: Line 21:
[[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
[[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
[[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
[[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
-
[[2k9y]], [[3e8n]] - hEPH A2 transmembrane domain – NMR<BR />
+
[[2k9y]], [[2e8n]] - hEPH A2 transmembrane domain – NMR<BR />
[[1mqb]] - hEPH A2 kinase domain<BR />
[[1mqb]] - hEPH A2 kinase domain<BR />
-
[[3mx0]], [[1x11]] - hEPH A2 ectodomain + ephrin A5<BR />
+
''Ephrin A2 receptor binary complex''
 +
[[3mx0]], [[2x11]] - hEPH A2 ectodomain + ephrin A5<BR />
[[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
[[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
-
[[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1
+
[[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1<br />
 +
[[2kso]] - hEPH A2 SAM + SHIP2<br />
===Ephrin A3 receptor===
===Ephrin A3 receptor===
[[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
[[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
Line 30: Line 33:
[[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
[[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
-
[[3dzq]] - hEPH A3 kinase domain + inhibitor
+
[[3dzq]] - hEPH A3 kinase domain + inhibitor<br />
 +
[[4g2f]] - hEPH A3 kinase domain (mutant) + inhibitor<br />
===Ephrin A4 receptor===
===Ephrin A4 receptor===
[[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
[[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
 +
[[4bk4]], [[4m4p]] - hEPH A4 ectodomain<br />
 +
[[2lw8]] - hEPH A4 LBD – NMR<br />
 +
[[2hel]] – mEPH A4 membrane and kinase domains – mouse<br />
 +
[[2y6m]] – mEPH A4 kinase domain<br />
 +
''Ephrin A4 receptor binary complex''
[[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
[[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
-
[[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain
+
[[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain<br />
 +
[[4bk5]], [[4bka]], [[4m4r]] - hEPH A4 ectodomain + ephrin A5 LBD<br />
 +
[[4bkf]] - hEPH A4 ectodomain + ephrin B3 LBD<br />
 +
[[2xyu]] – mEPH A4 kinase domain + inhibitor<br />
 +
[[2y6o]] – mEPH A4 kinase domain + cancer drug<br />
===Ephrin A5 receptor===
===Ephrin A5 receptor===
[[2r2p]] - hEPH A5 kinase domain<BR />
[[2r2p]] - hEPH A5 kinase domain<BR />
-
[[1shx]] - mEPH A5 – mouse
+
[[1shx]] - mEPH A5 <br />
 +
[[4et7]] – hEPH A5 (mutant)<br />
===Ephrin A7 receptor===
===Ephrin A7 receptor===
[[3nru]] – hEPH A7 LBD<BR />
[[3nru]] – hEPH A7 LBD<BR />
Line 50: Line 64:
[[2eao]] – hEPH B1 SAM – NMR<BR />
[[2eao]] – hEPH B1 SAM – NMR<BR />
[[2djs]] - hEPH B1 fn3 domain – NMR<BR />
[[2djs]] - hEPH B1 fn3 domain – NMR<BR />
 +
[[3zfx]] - hEPH B1 kinase domain<br />
===Ephrin B2 receptor===
===Ephrin B2 receptor===
[[3etp]] – hEPH B2<BR />
[[3etp]] – hEPH B2<BR />
[[1f0m]] – mEPH B2 SAM<BR />
[[1f0m]] – mEPH B2 SAM<BR />
 +
[[1iko]] - mEPH B2 ectodomain<br />
 +
[[2i85]] - hEPH B2 ectodomain<br />
[[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
[[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
 +
''Ephrin B2 receptor binary complex''
[[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
[[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
[[2qbx]] – hEPH B2 + peptide agonist<BR />
[[2qbx]] – hEPH B2 + peptide agonist<BR />
Line 59: Line 77:
[[1shw]] - mEPH B2 LBD + ephrin A5<BR />
[[1shw]] - mEPH B2 LBD + ephrin A5<BR />
[[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
[[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
-
[[1iko]] - mEPH B2 ectodomain
 
===Ephrin B3 receptor===
===Ephrin B3 receptor===
[[3p1i]] – hEPH B3 LBD<BR />
[[3p1i]] – hEPH B3 LBD<BR />
 +
[[3zfy]] - hEPH B3 kinase domain<br />
===Ephrin B4 receptor===
===Ephrin B4 receptor===
[[2qkq]] – hEPH B4 SAM<BR />
[[2qkq]] – hEPH B4 SAM<BR />
[[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
[[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
-
[[2x9f]] - hEPH B4 kinase domain (mutant) <BR />
+
[[2x9f]], [[2vwy]] - hEPH B4 kinase domain (mutant) <BR />
-
[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]] – hEPH B4 + inhibitor <BR />
+
''Ephrin B4 receptor binary complex''
 +
[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]], [[4aw5]] – hEPH B4 kinase domain + inhibitor <BR />
 +
[[3zew]] - hEPH B4 + staurosporine<br />
 +
[[2xvd]], [[2yn8]], [[4bb4]] - hEPH B4 kinase domain (mutant) + inhibitor<br />
[[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2
[[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2

Revision as of 09:22, 4 March 2014

Image:3hei.png
Crystal Structure of ephrin A2 receptor complex with ephrin, 3hei

Template:STRUCTURE 3fxx

Ephrin receptors (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see Ephrin Type-A Receptor.

Contents



3D Structures of ephrin receptors

Updated on 04-March-2014

Ephrin A1 receptor

3kka - hEPH A1 SAM+ hEPH A2 SAM – human
3hil - hEPH A1 SAM
2k1l - hEPH A1 transmembrane domain – NMR
1x5a - hEPH A1 fn3 domain – NMR

Ephrin A2 receptor

3hpn, 3c8x - hEPH A2 LBD
2x10, 3fl7 - hEPH A2 ectodomain
2k9y, 2e8n - hEPH A2 transmembrane domain – NMR
1mqb - hEPH A2 kinase domain
Ephrin A2 receptor binary complex 3mx0, 2x11 - hEPH A2 ectodomain + ephrin A5
3hei, 3czu - hEPH A2 LBD + ephrin A1
3mbw - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1
2kso - hEPH A2 SAM + SHIP2

Ephrin A3 receptor

2qo2, 2qob, 2gsf - hEPH A3 kinase domain
2qok, 2qol, 2qon, 2qoo, 2qod, 2qof, 2qoi - hEPH A3 kinase domain (mutant)
3fxx, 3fy2 – hEPH A3 kinase domain + peptide substrate
2qoq, 2qo7, 2qo9, 2qoc - hEPH A3 kinase domain + AMP-PNP
3dzq - hEPH A3 kinase domain + inhibitor
4g2f - hEPH A3 kinase domain (mutant) + inhibitor

Ephrin A4 receptor

2wo1, 3ckh - hEPH A4 LBD
4bk4, 4m4p - hEPH A4 ectodomain
2lw8 - hEPH A4 LBD – NMR
2hel – mEPH A4 membrane and kinase domains – mouse
2y6m – mEPH A4 kinase domain
Ephrin A4 receptor binary complex 2wo3 - hEPH A4 LBD + ephrin A2 receptor-binding domain
2wo2, 3gxu - hEPH A4 LBD + ephrin B2 receptor-binding domain
4bk5, 4bka, 4m4r - hEPH A4 ectodomain + ephrin A5 LBD
4bkf - hEPH A4 ectodomain + ephrin B3 LBD
2xyu – mEPH A4 kinase domain + inhibitor
2y6o – mEPH A4 kinase domain + cancer drug

Ephrin A5 receptor

2r2p - hEPH A5 kinase domain
1shx - mEPH A5
4et7 – hEPH A5 (mutant)

Ephrin A7 receptor

3nru – hEPH A7 LBD
3h8m – hEPH A7 SAM
2rei - hEPH A7 kinase domain
3dko – hEPH A7 kinase domain + inhibitor

Ephrin A8 receptor

3kul - hEPH A8 kinase domain
1x5l – hEPH A8 fn3 domain – NMR
1ucv - hEPH A8 SAM – NMR

Ephrin B1 receptor

2eao – hEPH B1 SAM – NMR
2djs - hEPH B1 fn3 domain – NMR
3zfx - hEPH B1 kinase domain

Ephrin B2 receptor

3etp – hEPH B2
1f0m – mEPH B2 SAM
1iko - mEPH B2 ectodomain
2i85 - hEPH B2 ectodomain
1sgg - mEPH B2 SAM – chicken - NMR
Ephrin B2 receptor binary complex 2vsk, 2vsm – hEPH B2 + Viral Hemagglutinin-neuraminidase
2qbx – hEPH B2 + peptide agonist
2hen - hEPH B2 kinase domain + ADP
1shw - mEPH B2 LBD + ephrin A5
1kgy - mEPH B2 LBD + ephrin B2 extracellular domain

Ephrin B3 receptor

3p1i – hEPH B3 LBD
3zfy - hEPH B3 kinase domain

Ephrin B4 receptor

2qkq – hEPH B4 SAM
2e7h – hEPH B4 fn3 domain - NMR
2x9f, 2vwy - hEPH B4 kinase domain (mutant)
Ephrin B4 receptor binary complex 2vwx, 2vwz, 2vx0, 2vx1, 2vwu, 2vwv, 2vww, 4aw5 – hEPH B4 kinase domain + inhibitor
3zew - hEPH B4 + staurosporine
2xvd, 2yn8, 4bb4 - hEPH B4 kinase domain (mutant) + inhibitor
2hle, 2bba - hEPH B4 LBD + ephrin B2

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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