426d
From Proteopedia
(New page: 200px<br /><applet load="426d" size="350" color="white" frame="true" align="right" spinBox="true" caption="426d, resolution 3.0Å" /> '''THE STRUCTURE OF MOST...) |
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==Overview== | ==Overview== | ||
| - | The title oligonucleotide and many related dodecamers have been | + | The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Liu, J.]] | [[Category: Liu, J.]] | ||
[[Category: Malinina, L.]] | [[Category: Malinina, L.]] | ||
| - | [[Category: Subirana, J | + | [[Category: Subirana, J A.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:12:13 2008'' |
Revision as of 17:12, 21 February 2008
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THE STRUCTURE OF MOST STUDIED DNA FRAGMENT CHANGES UNDER THE INFLUENCE OF IONS: A NEW PACKING OF D(CGCGAATTCGCG)
Overview
The title oligonucleotide and many related dodecamers have been extensively studied alone and as DNA-drug complexes. In practically all cases they were found to crystallize in the same space group, stabilized by interactions among the terminal guanine bases. Here we report new packing interactions (R3) in the presence of Ca2+. The oligonucleotides interact by placing their terminal guanines in the narrow groove of a neighbor molecule, an interaction which had never been found in dodecamers.
About this Structure
426D is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
The structure of the most studied DNA fragment changes under the influence of ions: a new packing of d(CGCGAATTCGCG)., Liu J, Malinina L, Huynh-Dinh T, Subirana JA, FEBS Lett. 1998 Nov 6;438(3):211-4. PMID:9827547
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