Farnesyl diphosphate synthase

From Proteopedia

Revision as of 09:28, 11 March 2014

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Farnesyl diphosphate synthase (FPS) also named farnesyl pyrophosphate synthase catalyzes the conversion of geranyl diphosphate (GDP) and isopentenyl diphosphate (IPP) to farnesyl diphosphate and diphosphate.

3D structures of farnesyl diphosphate synthase

Updated on 11-March-2014

1fps– cFPS – chicken
1ubv – cFPS (mutant)
1zw5, 2f7m – hFPS – human
1rtr– FPS – Staphylococcus aureus
1yhk – TcFPS – Trypanosoma cruzi
3lvs, 3m0g – FPS – Rhodobacter capsulatus
3m9u – LbFPS – Lactobacillus brevis

FPS binary complexes

1yq7, 1yv5, 2f89, 2f8c, 2f92, 2f94, 2f9k, 2rah, 2opn, 2vf6, 3b7l, 2opm, 3n1v, 3n1w, 3n3l, 3n45, 3n46, 3n49, 3n5j, 3n6k, 3n5h, 4dem, 4ga3, 4jvj - hFPS + inhibitor
2qis, 3cp6, 3rye, 3s4j - hFPS (mutant) + inhibitor
2i19, 2ewg, 2ogd, 2p1c, 3dyg, 3dyh, 3efq, 3egt - TbFPS + inhibitor – Trypanosoma brucei
1ubw, 1ubx - cFPS (mutant) + GDP
1uby - cFPS (mutant) + dimethylallyl diphosphate
2for– FPS + IPP – Shigella flexneri
3id0– TcFPS + inhibitor
3pde – LbFPS + IPP

FPS ternary complexes

2f8z, 4h5e - hFPS + IPP + inhibitor
4h5c, 4h3c, 4h5d - hFPS + phosphate + inhibitor
1rqi – EcFPS + IPP + dimethylallyl S-thiolodiphosphate – Escherichia coli
1rqj - EcFPS + IPP + inhibitor
1yhl – TcFPS + dimethylallyl diphosphate + inhibitor
1yhm, 3iba, 3ick, 3icm, 3icn, 3icz, 4dwb, 4dwg, 4dxj, 4dzw, 4e1e - TcFPS + IPP + inhibitor
3ez3 - PvFPS + IPP + inhibitor – Plasmodium vivax
3dyf - TbFPS + IPP + inhibitor