486d
From Proteopedia
(New page: 200px<br /><applet load="486d" size="350" color="white" frame="true" align="right" spinBox="true" caption="486d, resolution 7.5Å" /> '''X-RAY CRYSTAL STRUCTU...) |
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==Overview== | ==Overview== | ||
| - | Structures of 70S ribosome complexes containing messenger RNA and transfer | + | Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of the interactions between tRNA and the ribosome, and of the packing arrangements of ribosomal RNA (rRNA) helices in and between the ribosomal subunits, can be seen. Numerous contacts are made between the 30S subunit and the P-tRNA anticodon stem-loop; in contrast, the anticodon region of A-tRNA is much more exposed. A complex network of molecular interactions suggestive of a functional relay is centered around the long penultimate stem of 16S rRNA at the subunit interface, including interactions involving the "switch" helix and decoding site of 16S rRNA, and RNA bridges from the 50S subunit. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| - | [[Category: Cate, J | + | [[Category: Cate, J H.]] |
| - | [[Category: Earnest, T | + | [[Category: Earnest, T N.]] |
| - | [[Category: Noller, H | + | [[Category: Noller, H F.]] |
| - | [[Category: Yusupov, M | + | [[Category: Yusupov, M M.]] |
| - | [[Category: Yusupova, G | + | [[Category: Yusupova, G Zh.]] |
[[Category: IR]] | [[Category: IR]] | ||
[[Category: functional models of 70s ribosome]] | [[Category: functional models of 70s ribosome]] | ||
[[Category: trna]] | [[Category: trna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:12:37 2008'' |
Revision as of 17:12, 21 February 2008
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X-RAY CRYSTAL STRUCTURES OF 70S RIBOSOME FUNCTIONAL COMPLEXES
Overview
Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of the interactions between tRNA and the ribosome, and of the packing arrangements of ribosomal RNA (rRNA) helices in and between the ribosomal subunits, can be seen. Numerous contacts are made between the 30S subunit and the P-tRNA anticodon stem-loop; in contrast, the anticodon region of A-tRNA is much more exposed. A complex network of molecular interactions suggestive of a functional relay is centered around the long penultimate stem of 16S rRNA at the subunit interface, including interactions involving the "switch" helix and decoding site of 16S rRNA, and RNA bridges from the 50S subunit.
About this Structure
486D is a Protein complex structure of sequences from Escherichia coli, Saccharomyces cerevisiae and Thermus thermophilus with as ligand. Full crystallographic information is available from OCA.
Reference
X-ray crystal structures of 70S ribosome functional complexes., Cate JH, Yusupov MM, Yusupova GZ, Earnest TN, Noller HF, Science. 1999 Sep 24;285(5436):2095-104. PMID:10497122
Page seeded by OCA on Thu Feb 21 19:12:37 2008
