4nf8
From Proteopedia
(Difference between revisions)
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- | + | {{STRUCTURE_4nf8| PDB=4nf8 | SCENE= }} | |
+ | ===Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME=== | ||
+ | {{ABSTRACT_PUBMED_24462099}} | ||
- | + | ==Function== | |
+ | [[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. | ||
- | + | ==About this Structure== | |
+ | [[4nf8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NF8 OCA]. | ||
- | + | ==Reference== | |
+ | <ref group="xtra">PMID:024462099</ref><references group="xtra"/><references/> | ||
+ | [[Category: Furukawa, H.]] | ||
+ | [[Category: Jespersen, A.]] | ||
+ | [[Category: Tajima, N.]] | ||
+ | [[Category: Glycine and glutamate]] | ||
+ | [[Category: Receptor]] | ||
+ | [[Category: Transport protein]] |
Revision as of 13:36, 12 March 2014
Contents |
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME
Template:ABSTRACT PUBMED 24462099
Function
[NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.[1] [NMDE1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
About this Structure
4nf8 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Jespersen A, Tajima N, Fernandez-Cuervo G, Garnier-Amblard EC, Furukawa H. Structural insights into competitive antagonism in NMDA receptors. Neuron. 2014 Jan 22;81(2):366-78. doi: 10.1016/j.neuron.2013.11.033. PMID:24462099 doi:http://dx.doi.org/10.1016/j.neuron.2013.11.033
- ↑ Inanobe A, Furukawa H, Gouaux E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84. PMID:15996549 doi:10.1016/j.neuron.2005.05.022