4oh3

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m (Protected "4oh3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4oh3| PDB=4oh3 | SCENE= }}
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===Crystal structure of a nitrate transporter===
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{{ABSTRACT_PUBMED_24572362}}
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The entry 4oh3 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PTR7_ARATH PTR7_ARATH]] Dual affinity nitrate transporter. Involved in proton-dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be involved in the basipetal transport of auxin out of the lateral root tips. Acts as a bidirectional transporter involved in root-to-shoot nitrate translocation.<ref>PMID:8453665</ref> <ref>PMID:9844028</ref> <ref>PMID:12606566</ref> <ref>PMID:12509525</ref> <ref>PMID:15319483</ref> <ref>PMID:17148611</ref> <ref>PMID:19766570</ref> <ref>PMID:19633234</ref> <ref>PMID:20627075</ref>
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Authors: Sun, J., Bankston, J.R., Payandeh, J., Hinds, T.R., Zagotta, W.N., Zheng, N.
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==About this Structure==
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[[4oh3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OH3 OCA].
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Description: Crystal structure of a nitrate transporter
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==Reference==
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<ref group="xtra">PMID:024572362</ref><references group="xtra"/><references/>
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[[Category: Bankston, J R.]]
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[[Category: Hinds, T R.]]
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[[Category: Payandeh, J.]]
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[[Category: Sun, J.]]
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[[Category: Zagotta, W N.]]
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[[Category: Zheng, N.]]
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[[Category: Major facilitator superfamily]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Nitrate transporter]]
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[[Category: Tranport protein]]

Revision as of 13:43, 12 March 2014

Template:STRUCTURE 4oh3

Contents

Crystal structure of a nitrate transporter

Template:ABSTRACT PUBMED 24572362

Function

[PTR7_ARATH] Dual affinity nitrate transporter. Involved in proton-dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be involved in the basipetal transport of auxin out of the lateral root tips. Acts as a bidirectional transporter involved in root-to-shoot nitrate translocation.[1] [2] [3] [4] [5] [6] [7] [8] [9]

About this Structure

4oh3 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Sun J, Bankston JR, Payandeh J, Hinds TR, Zagotta WN, Zheng N. Crystal structure of the plant dual-affinity nitrate transporter NRT1.1. Nature. 2014 Mar 6;507(7490):73-7. doi: 10.1038/nature13074. Epub 2014 Feb 26. PMID:24572362 doi:http://dx.doi.org/10.1038/nature13074
  1. ↑ Tsay YF, Schroeder JI, Feldmann KA, Crawford NM. The herbicide sensitivity gene CHL1 of Arabidopsis encodes a nitrate-inducible nitrate transporter. Cell. 1993 Mar 12;72(5):705-13. PMID:8453665
  2. ↑ Wang R, Liu D, Crawford NM. The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15134-9. PMID:9844028
  3. ↑ Liu KH, Tsay YF. Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation. EMBO J. 2003 Mar 3;22(5):1005-13. PMID:12606566 doi:http://dx.doi.org/10.1093/emboj/cdg118
  4. ↑ Guo FQ, Young J, Crawford NM. The nitrate transporter AtNRT1.1 (CHL1) functions in stomatal opening and contributes to drought susceptibility in Arabidopsis. Plant Cell. 2003 Jan;15(1):107-17. PMID:12509525
  5. ↑ Munos S, Cazettes C, Fizames C, Gaymard F, Tillard P, Lepetit M, Lejay L, Gojon A. Transcript profiling in the chl1-5 mutant of Arabidopsis reveals a role of the nitrate transporter NRT1.1 in the regulation of another nitrate transporter, NRT2.1. Plant Cell. 2004 Sep;16(9):2433-47. Epub 2004 Aug 19. PMID:15319483 doi:http://dx.doi.org/10.1105/tpc.104.024380
  6. ↑ Remans T, Nacry P, Pervent M, Filleur S, Diatloff E, Mounier E, Tillard P, Forde BG, Gojon A. The Arabidopsis NRT1.1 transporter participates in the signaling pathway triggering root colonization of nitrate-rich patches. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19206-11. Epub 2006 Dec 5. PMID:17148611 doi:http://dx.doi.org/10.1073/pnas.0605275103
  7. ↑ Ho CH, Lin SH, Hu HC, Tsay YF. CHL1 functions as a nitrate sensor in plants. Cell. 2009 Sep 18;138(6):1184-94. doi: 10.1016/j.cell.2009.07.004. PMID:19766570 doi:http://dx.doi.org/10.1016/j.cell.2009.07.004
  8. ↑ Wang R, Xing X, Wang Y, Tran A, Crawford NM. A genetic screen for nitrate regulatory mutants captures the nitrate transporter gene NRT1.1. Plant Physiol. 2009 Sep;151(1):472-8. doi: 10.1104/pp.109.140434. Epub 2009 Jul, 24. PMID:19633234 doi:http://dx.doi.org/10.1104/pp.109.140434
  9. ↑ Krouk G, Lacombe B, Bielach A, Perrine-Walker F, Malinska K, Mounier E, Hoyerova K, Tillard P, Leon S, Ljung K, Zazimalova E, Benkova E, Nacry P, Gojon A. Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. Dev Cell. 2010 Jun 15;18(6):927-37. doi: 10.1016/j.devcel.2010.05.008. PMID:20627075 doi:http://dx.doi.org/10.1016/j.devcel.2010.05.008

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