4oq5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4oq5" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4oq5| PDB=4oq5 | SCENE= }}
 +
===Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid===
 +
{{ABSTRACT_PUBMED_24582986}}
-
The entry 4oq5 is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
-
Authors: Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
+
==About this Structure==
 +
[[4oq5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA].
-
Description:
+
==Reference==
 +
<ref group="xtra">PMID:024582986</ref><references group="xtra"/><references/>
 +
[[Category: Kunzer, A R.]]
 +
[[Category: Park, C.]]
 +
[[Category: Petros, A M.]]
 +
[[Category: Song, D.]]
 +
[[Category: Souers, A J.]]
 +
[[Category: Sun, C.]]
 +
[[Category: Swann, S L.]]
 +
[[Category: Swinger, K.]]
 +
[[Category: Wendt, M D.]]
 +
[[Category: Zhang, H.]]
 +
[[Category: Apoptosis-inhibitor complex]]

Revision as of 13:47, 12 March 2014

Template:STRUCTURE 4oq5

Contents

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

Template:ABSTRACT PUBMED 24582986

Function

[MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.[1]

About this Structure

4oq5 is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Petros AM, Swann SL, Song D, Swinger K, Park C, Zhang H, Wendt MD, Kunzer AR, Souers AJ, Sun C. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1484-8. doi: 10.1016/j.bmcl.2014.02.010. , Epub 2014 Feb 14. PMID:24582986 doi:http://dx.doi.org/10.1016/j.bmcl.2014.02.010
  1. ↑ Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK. Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J Biol Chem. 2000 Jul 21;275(29):22136-46. PMID:10766760 doi:10.1074/jbc.M909572199

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4oq5"
Personal tools