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4oq5

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m (Protected "4oq5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4oq5| PDB=4oq5 | SCENE= }}
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===Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid===
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{{ABSTRACT_PUBMED_24582986}}
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The entry 4oq5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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Authors: Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
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==About this Structure==
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[[4oq5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA].
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Description:
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==Reference==
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<ref group="xtra">PMID:024582986</ref><references group="xtra"/><references/>
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[[Category: Kunzer, A R.]]
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[[Category: Park, C.]]
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[[Category: Petros, A M.]]
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[[Category: Song, D.]]
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[[Category: Souers, A J.]]
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[[Category: Sun, C.]]
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[[Category: Swann, S L.]]
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[[Category: Swinger, K.]]
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[[Category: Wendt, M D.]]
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[[Category: Zhang, H.]]
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[[Category: Apoptosis-inhibitor complex]]

Revision as of 13:47, 12 March 2014

Template:STRUCTURE 4oq5

Contents

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

Template:ABSTRACT PUBMED 24582986

Function

[MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.[1]

About this Structure

4oq5 is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Petros AM, Swann SL, Song D, Swinger K, Park C, Zhang H, Wendt MD, Kunzer AR, Souers AJ, Sun C. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1484-8. doi: 10.1016/j.bmcl.2014.02.010. , Epub 2014 Feb 14. PMID:24582986 doi:http://dx.doi.org/10.1016/j.bmcl.2014.02.010
  1. ↑ Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK. Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J Biol Chem. 2000 Jul 21;275(29):22136-46. PMID:10766760 doi:10.1074/jbc.M909572199

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