4lfv

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'''Unreleased structure'''
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{{STRUCTURE_4lfv| PDB=4lfv | SCENE= }}
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===Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate===
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The entry 4lfv is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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Authors: Park, J., Lin, Y.-S., Tsantrizos, Y.S., Berghuis, A.M.
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==About this Structure==
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[[4lfv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LFV OCA].
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Description: Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate
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[[Category: Berghuis, A M.]]
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[[Category: Lin, Y S.]]
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[[Category: Park, J.]]
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[[Category: Tsantrizos, Y S.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 13:59, 12 March 2014

Template:STRUCTURE 4lfv

Crystal structure of human FPPS in complex with YS0470 and two molecules of inorganic phosphate

Function

[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

About this Structure

4lfv is a 1 chain structure. Full crystallographic information is available from OCA.

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OCA

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