4n8m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4n8m| PDB=4n8m | SCENE= }}
 +
===Structural polymorphism in the N-terminal oligomerization domain of NPM1===
-
The entry 4n8m is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/NPM_MOUSE NPM_MOUSE]] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity).
-
Authors: Mitrea, D., Royappa, G., Buljan, M., Yun, M., Pytel, N., Satumba, J., Nourse, A., Park, C., Babu, M.M., White, S.W., Kriwacki, R.W.
+
==About this Structure==
-
 
+
[[4n8m]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8M OCA].
-
Description: Structural polymorphism in the n-terminal domain of npm1 modulates its nucleolar chaperone functions
+
[[Category: Babu, M M.]]
 +
[[Category: Buljan, M.]]
 +
[[Category: Kriwacki, R W.]]
 +
[[Category: Mitrea, D.]]
 +
[[Category: Nourse, A.]]
 +
[[Category: Park, C.]]
 +
[[Category: Pytel, N.]]
 +
[[Category: Royappa, G.]]
 +
[[Category: Satumba, J.]]
 +
[[Category: White, S W.]]
 +
[[Category: Yun, M.]]
 +
[[Category: Chaperone]]
 +
[[Category: Histone chaperone]]
 +
[[Category: Nucleolar protein]]
 +
[[Category: Pentamer]]
 +
[[Category: Phosphoprotein]]
 +
[[Category: Regulated unfolding]]
 +
[[Category: Ribosome biogenesis]]
 +
[[Category: Structural polymorphism]]

Revision as of 14:01, 12 March 2014

Template:STRUCTURE 4n8m

Structural polymorphism in the N-terminal oligomerization domain of NPM1

Function

[NPM_MOUSE] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity).

About this Structure

4n8m is a 5 chain structure. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4n8m"
Personal tools