3rmj

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[[Image:3rmj.jpg|left|200px]]
 
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{{STRUCTURE_3rmj| PDB=3rmj | SCENE= }}
{{STRUCTURE_3rmj| PDB=3rmj | SCENE= }}
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===Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis===
===Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis===
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{{ABSTRACT_PUBMED_22352945}}
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==Function==
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[[http://www.uniprot.org/uniprot/LEU1_NEIMB LEU1_NEIMB]] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 22352945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22352945}}
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==About this Structure==
==About this Structure==
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[[3rmj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMJ OCA].
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[[3rmj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neimi Neimi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMJ OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:022352945</ref><references group="xtra"/>
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<ref group="xtra">PMID:022352945</ref><references group="xtra"/><references/>
[[Category: 2-isopropylmalate synthase]]
[[Category: 2-isopropylmalate synthase]]
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[[Category: Neisseria meningitidis]]
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[[Category: Neimi]]
[[Category: Baker, E N.]]
[[Category: Baker, E N.]]
[[Category: Baker, H M.]]
[[Category: Baker, H M.]]

Revision as of 14:16, 12 March 2014

Template:STRUCTURE 3rmj

Contents

Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis

Template:ABSTRACT PUBMED 22352945

Function

[LEU1_NEIMB] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).

About this Structure

3rmj is a 2 chain structure with sequence from Neimi. Full crystallographic information is available from OCA.

Reference

  • Huisman FH, Koon N, Bulloch EM, Baker HM, Baker EN, Squire CJ, Parker EJ. Removal of the C-Terminal Regulatory Domain of alpha-Isopropylmalate Synthase Disrupts Functional Substrate Binding. Biochemistry. 2012 Mar 6. PMID:22352945 doi:10.1021/bi201717j

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