4kty
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | [[4kty]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTY OCA]. | + | [[4kty]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTY OCA]. |
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| + | ==See Also== | ||
| + | *[[Factor XIII|Factor XIII]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024115223</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024115223</ref><references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Protein-glutamine gamma-glutamyltransferase]] | [[Category: Protein-glutamine gamma-glutamyltransferase]] | ||
[[Category: Heine, A.]] | [[Category: Heine, A.]] | ||
Revision as of 14:27, 12 March 2014
Contents |
Fibrin-stabilizing factor with a bound ligand
Template:ABSTRACT PUBMED 24115223
Disease
[F13A_HUMAN] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.[1]
Function
[F13A_HUMAN] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
About this Structure
4kty is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Stieler M, Weber J, Hils M, Kolb P, Heine A, Buchold C, Pasternack R, Klebe G. Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next-Generation Anticoagulants. Angew Chem Int Ed Engl. 2013 Sep 20. doi: 10.1002/anie.201305133. PMID:24115223 doi:http://dx.doi.org/10.1002/anie.201305133
