Hydroxysteroid dehydrogenase

From Proteopedia

Revision as of 09:07, 18 March 2014

Template:STRUCTURE 1lwi Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classdified according to the number of carbon it is acting on. 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme. 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme. 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 11-β HSD converts 11-keto products like cortisone to cortisol. 17-β HSD is involved in the conversion of androstenedione to testosterone. 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17. NAD and NADP are cofactors of HSD.

3D structures of hydroxysteroid dehydrogenase

Updated on 18-March-2014

3-α HSD

For 3-α HSD type 2 see Prostaglandin F synthase

1ral – rHSD – rat
1fjh - CtHSD – Comamonas testosterone
3fjn - mHSD (mutant) - mouse
4is2 – CsHSD – Clostridium scindens

3-α HSD binary complex

1lwi – rHSD + NADP
1fk8 – CtHSD + NAD
2fvl, 2hdj - hHSD + NADP
2dkn - HSD + NAD – Pseudomonas
2p5n - mHSD + NADP
4is3 - CsHSD + NAD

3-α HSD ternary complex

1ihi, 1j96 - hHSD + hydroxysteroid + NADP – human
1afs - rHSD + hydroxysteroid + NADP
2ipf - mHSD + hydroxysteroid + NADP
2ipg, 2ipj - mHSD (mutant) + hydroxysteroid + NADP
3cv6 - mHSD (mutant) + inhibitor + NADP

7-α HSD

3gaf - HSD – Brucella melitensis
1ahh – EcHSD + NAD – Escherichia coli
1ahi, 1fmc – EcHSD + hydroxysteroid + NAD

20-α HSD

1q5m - raHSD + NADP – rabbit

20-α HSD ternary complex

1mrq – hHSD + hydroxysteroid + NADP
3c3u, 3nty - hHSD + inhibitor + NADP
3gug - hHSD (mutant) + inhibitor + NADP
1q13 - raHSD + hydroxysteroid + NADP

11-β HSD

1xu7, 1xu9 - hHSD (mutant) + NADP
2pd6 - hHSD + NAD
1y5m - mHSD + NADP
1xse - gpHSD catalytic domain + NADP – guinea pig
3hb4 - hHSD + inhibitor
3dey - hHSD + hydroxysteroid
3dwf, 3lz6 - gpHSD catalytic domain (mutant) + NADP

11-β HSD ternary complex

3g49 - gpHSD catalytic domain + inhibitor + NADP
1y5r, 3gmd - mHSD + hydroxysteroid + NADP
2bel - hHSD + hydroxysteroid + NADP
2irw, 2ilt - hHSD + inhibitor + NADP
2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3frj, 3hfg, 3fco, 3h6k, 3oq1, 3pdj, 3tfq, 3qqp - hHSD (mutant) + inhibitor + NADP

17-β HSD

For 17-β HSD type 5 see Prostaglandin F synthase

1bhs – hHSD
1s9c - hHSD (mutant)
3is3 – ClHSD – Cochliobolus lunatus
3itd - ClHSD (mutant)

17-β HSD binary complex

3qwf - ClHSD + NADP
4fj0, 4fj1, 4fj2, 4fiz – ClHSD + dehydroxy flavonoid inhibitor
1fdw, 1dht - hHSD (mutant) + hydroxysteroid
1jtv, 1yb1, 3dhe, 1fds, 1iol, 3klm, 3klp, 3km0 - hHSD + hydroxysteroid 1fdv - hHSD (mutant) + NAD
1zbq - hHSD + NAD
1qyv - hHSD + NADP
1i5r - hHSD + inhibitor

17-β HSD ternary complex

1qyw, 1qyx, 1fdt - hHSD + hydroxysteroid + NADP
1a27, 1fdu - hHSD (mutant) + hydroxysteroid + NADP
3hb5 - hHSD + inhibitor + NADP
3qwi, 3qwh - ClHSD + hydroxysteroid + NADP

3-α 20-β HSD

2hsd – SeHSD – Streptomyces exfoliates
1hdc – SeHSD + inhibitor

3-β/17-β HSD

1hxh - CtHSD