Sandbox reserved 914
From Proteopedia
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==Palmitoyl-Protein Thioesterase 1 == | ==Palmitoyl-Protein Thioesterase 1 == | ||
<StructureSection load='3rec' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3rec' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | [[Image:sandbox1.png| | + | [[Image:sandbox1.png|300px|left|thumb|Figure Legend]] |
Palmitoyl-Protein Thioesterase 1 (PPT1) is a lysosomal enzyme that plays a role in the degradation of lipid-modified proteins. PPT1 receives its catalytic power from its catalytic triad, the α/β hydrolase fold, and its hydrophobic groove in order to remove fatty acid acyl groups, typically palmitate from cysteine residues in proteins. PPT1 demonstrates how proteins can be modified by different enzymes and induce biological changes. Misregulation of PPT1 modifications can cause various diseases, including infantile neuronal ceroid lipofuscinosis, kufs disease, and late-infantile neuronal ceroid lipofuscinosis. Within these diseases, the production of PPT1 is decreased or eliminated completely, which leads to fatty acid buildup. | Palmitoyl-Protein Thioesterase 1 (PPT1) is a lysosomal enzyme that plays a role in the degradation of lipid-modified proteins. PPT1 receives its catalytic power from its catalytic triad, the α/β hydrolase fold, and its hydrophobic groove in order to remove fatty acid acyl groups, typically palmitate from cysteine residues in proteins. PPT1 demonstrates how proteins can be modified by different enzymes and induce biological changes. Misregulation of PPT1 modifications can cause various diseases, including infantile neuronal ceroid lipofuscinosis, kufs disease, and late-infantile neuronal ceroid lipofuscinosis. Within these diseases, the production of PPT1 is decreased or eliminated completely, which leads to fatty acid buildup. | ||
Revision as of 13:13, 18 March 2014
Palmitoyl-Protein Thioesterase 1
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