4igs

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'''Unreleased structure'''
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{{STRUCTURE_4igs| PDB=4igs | SCENE= }}
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===Crystal structure of human Aldose Reductase complexed with NADP+ and JF0064===
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{{ABSTRACT_PUBMED_24598757}}
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The entry 4igs is ON HOLD until Mar 17 2015
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==Function==
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[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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Authors: Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Porte, S., de Lera, A.R., Martin, M.J., de la Fuente, J.A., Klebe, G., Farres, J., Pares, X., Podjarny, A.
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==About this Structure==
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[[4igs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGS OCA].
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Description: Crystal structure of human Aldose Reductase complexed with NADP+ and JF0064
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==Reference==
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<ref group="xtra">PMID:024598757</ref><references group="xtra"/><references/>
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[[Category: Aldehyde reductase]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Farres, J.]]
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[[Category: Fuente, J A.de la.]]
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[[Category: Klebe, G.]]
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[[Category: Lera, A R.de.]]
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[[Category: Martin, M J.]]
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[[Category: Mitschler, A.]]
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[[Category: Pares, X.]]
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[[Category: Podjarny, A.]]
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[[Category: Porte, S.]]
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[[Category: Ruiz, F X.]]
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[[Category: Aldose reductase]]
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[[Category: Cytosolic]]
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[[Category: Diabetes]]
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[[Category: Halogenated compound]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim barrel]]

Revision as of 08:44, 19 March 2014

Template:STRUCTURE 4igs

Contents

Crystal structure of human Aldose Reductase complexed with NADP+ and JF0064

Template:ABSTRACT PUBMED 24598757

Function

[ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

About this Structure

4igs is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Cousido-Siah A, Ruiz FX, Mitschler A, Porte S, de Lera AR, Martin MJ, Manzanaro S, de la Fuente JA, Terwesten F, Betz M, Klebe G, Farres J, Pares X, Podjarny A. Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):889-903. doi:, 10.1107/S1399004713033452. Epub 2014 Feb 27. PMID:24598757 doi:http://dx.doi.org/10.1107/S1399004713033452

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OCA

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