4miw

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'''Unreleased structure'''
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{{STRUCTURE_4miw| PDB=4miw | SCENE= }}
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===High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase===
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{{ABSTRACT_PUBMED_24516554}}
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The entry 4miw is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/Q6GWS2_9VIRU Q6GWS2_9VIRU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]
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Authors: Wallat, G.D., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
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==About this Structure==
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[[4miw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MIW OCA].
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Description: High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase
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==Reference==
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<ref group="xtra">PMID:024516554</ref><references group="xtra"/><references/>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Dong, C.]]
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[[Category: Dong, H.]]
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[[Category: Huang, Q.]]
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[[Category: Liang, Y.]]
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[[Category: Ly, H.]]
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[[Category: Wallat, G D.]]
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[[Category: Wang, W.]]
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[[Category: Beta sheet]]
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[[Category: Endonuclease]]
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[[Category: Endoribonuclease type ii]]
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[[Category: Helix]]
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[[Category: Transferase]]
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[[Category: Viral protein]]

Revision as of 08:47, 19 March 2014

Template:STRUCTURE 4miw

Contents

High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase

Template:ABSTRACT PUBMED 24516554

Function

[Q6GWS2_9VIRU] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]

About this Structure

4miw is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wallat GD, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase in complex with magnesium ions. PLoS One. 2014 Feb 7;9(2):e87577. doi: 10.1371/journal.pone.0087577. eCollection , 2014. PMID:24516554 doi:http://dx.doi.org/10.1371/journal.pone.0087577

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OCA

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