4mqo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4mqo| PDB=4mqo | SCENE= }}
 +
===Mycobaterium tuberculosis transaminase BioA complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE===
 +
{{ABSTRACT_PUBMED_24482078}}
-
The entry 4mqo is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU]] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref>
-
Authors: Finzel, B.C, Dai, R, Geders, T.W
+
==About this Structure==
 +
[[4mqo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQO OCA].
-
Description: Mycobaterium tuberculosis transaminase BioA complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE
+
==Reference==
 +
<ref group="xtra">PMID:024482078</ref><references group="xtra"/><references/>
 +
[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
 +
[[Category: Dai, R]]
 +
[[Category: Finzel, B C]]
 +
[[Category: Geders, T W]]
 +
[[Category: Transaminase]]
 +
[[Category: Transferase]]

Revision as of 08:53, 19 March 2014

Template:STRUCTURE 4mqo

Contents

Mycobaterium tuberculosis transaminase BioA complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE

Template:ABSTRACT PUBMED 24482078

Function

[BIOA_MYCTU] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.[1]

About this Structure

4mqo is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Dai R, Wilson DJ, Geders TW, Aldrich CC, Finzel BC. Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides. Chembiochem. 2014 Mar 3;15(4):575-86. doi: 10.1002/cbic.201300748. Epub 2014 Jan , 31. PMID:24482078 doi:http://dx.doi.org/10.1002/cbic.201300748
  1. ↑ Mann S, Ploux O. 7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies. FEBS J. 2006 Oct;273(20):4778-89. Epub 2006 Sep 19. PMID:16984394 doi:10.1111/j.1742-4658.2006.05479.x

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mqo"
Personal tools