4ku1
From Proteopedia
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{{STRUCTURE_4ku1| PDB=4ku1 | SCENE= }} | {{STRUCTURE_4ku1| PDB=4ku1 | SCENE= }} | ||
===Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering=== | ===Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering=== | ||
| + | {{ABSTRACT_PUBMED_24522230}} | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
[[4ku1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KU1 OCA]. | [[4ku1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KU1 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024522230</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Barb, A W.]] | [[Category: Barb, A W.]] | ||
Revision as of 08:58, 19 March 2014
Contents |
Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering
Template:ABSTRACT PUBMED 24522230
Disease
[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
About this Structure
4ku1 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Frank M, Walker RC, Lanzilotta WN, Prestegard JH, Barb AW. Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering. J Mol Biol. 2014 Feb 9. pii: S0022-2836(14)00069-2. doi:, 10.1016/j.jmb.2014.01.011. PMID:24522230 doi:http://dx.doi.org/10.1016/j.jmb.2014.01.011
