4ckl

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{{STRUCTURE_4ckl| PDB=4ckl | SCENE= }}
{{STRUCTURE_4ckl| PDB=4ckl | SCENE= }}
===Structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit with simocyclinone D8 bound===
===Structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit with simocyclinone D8 bound===
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{{ABSTRACT_PUBMED_24594357}}
==Function==
==Function==
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==About this Structure==
==About this Structure==
[[4ckl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKL OCA].
[[4ckl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKL OCA].
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==See Also==
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*[[Gyrase|Gyrase]]
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==Reference==
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<ref group="xtra">PMID:024594357</ref><references group="xtra"/><references/>
[[Category: Edwards, M J.]]
[[Category: Edwards, M J.]]
[[Category: Hearnshaw, S J.]]
[[Category: Hearnshaw, S J.]]

Revision as of 09:04, 19 March 2014

Template:STRUCTURE 4ckl

Contents

Structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit with simocyclinone D8 bound

Template:ABSTRACT PUBMED 24594357

Function

[GYRA_SHIFL] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).

About this Structure

4ckl is a 2 chain structure. Full crystallographic information is available from OCA.

See Also

Reference

  • Hearnshaw SJ, Edwards MJ, Stevenson CE, Lawson DM, Maxwell A. A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition. J Mol Biol. 2014 Mar 1. pii: S0022-2836(14)00099-0. doi:, 10.1016/j.jmb.2014.02.017. PMID:24594357 doi:http://dx.doi.org/10.1016/j.jmb.2014.02.017

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