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4hoe

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4hoe| PDB=4hoe | SCENE= }}
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===Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)===
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{{ABSTRACT_PUBMED_24568657}}
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The entry 4hoe is ON HOLD until Mar 15 2015
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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Authors: Paulsen, J.L., Anderson, A.C.
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==About this Structure==
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[[4hoe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOE OCA].
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Description: Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)
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==Reference==
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<ref group="xtra">PMID:024568657</ref><references group="xtra"/><references/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Anderson, A C.]]
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[[Category: Paulsen, J L.]]
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[[Category: Antifungal agent]]
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[[Category: Candida albican]]
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[[Category: Drug design]]
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[[Category: Enzyme inhibitor]]
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[[Category: Fungal protein]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structure-activity relationship]]
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[[Category: Tetrahydrofolate dehydrogenase]]

Revision as of 09:06, 19 March 2014

Template:STRUCTURE 4hoe

Contents

Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)

Template:ABSTRACT PUBMED 24568657

Function

[DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4hoe is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J Med Chem. 2014 Mar 6. PMID:24568657 doi:http://dx.doi.org/10.1021/jm401916j

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OCA

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