4nn5

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'''Unreleased structure'''
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{{STRUCTURE_4nn5| PDB=4nn5 | SCENE= }}
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===Cytokine receptor complex - Crystal form 1A===
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The entry 4nn5 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE]] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [[http://www.uniprot.org/uniprot/CRLF2_MOUSE CRLF2_MOUSE]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
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Authors: Verstraete, K., van Schie, L., Savvides, S.N.
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==About this Structure==
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[[4nn5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN5 OCA].
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Description: Cytokine receptor complex -Crystal form 1A
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[[Category: Savvides, S N.]]
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[[Category: Schie, L van.]]
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[[Category: Verstraete, K.]]
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[[Category: Cell surface]]
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[[Category: Chr domain]]
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[[Category: Cytokine-cytokine receptor complex]]
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[[Category: Four helical bundle fold]]
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[[Category: Tslp cytokine signaling]]
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[[Category: Tslpr and il-7ralpha receptor]]

Revision as of 09:40, 19 March 2014

Template:STRUCTURE 4nn5

Cytokine receptor complex - Crystal form 1A

Function

[TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [CRLF2_MOUSE] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [IL7RA_MOUSE] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

About this Structure

4nn5 is a 3 chain structure. Full crystallographic information is available from OCA.

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OCA

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