4o7x

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'''Unreleased structure'''
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{{STRUCTURE_4o7x| PDB=4o7x | SCENE= }}
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===Crystal structure of human ALKBH5 in complex with Mn2+===
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The entry 4o7x is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>
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Authors: Feng, C., Chen, Z., Liu, Y.
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==About this Structure==
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[[4o7x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7X OCA].
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Description: Crystal structure of human ALKBH5 in complex with Mn2+
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Chen, Z.]]
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[[Category: Feng, C.]]
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[[Category: Liu, Y.]]
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[[Category: 6-methyl adenosine]]
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[[Category: Demethylation]]
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[[Category: Human dioxygenase]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase]]
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[[Category: Protein/dna interaction]]
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[[Category: Rna repair]]

Revision as of 09:42, 19 March 2014

Template:STRUCTURE 4o7x

Contents

Crystal structure of human ALKBH5 in complex with Mn2+

Function

[ALKB5_HUMAN] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.[1] [2]

About this Structure

4o7x is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schodel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF-1alpha). PLoS One. 2011 Jan 14;6(1):e16210. doi: 10.1371/journal.pone.0016210. PMID:21264265 doi:http://dx.doi.org/10.1371/journal.pone.0016210
  2. ↑ Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012, Nov 21. PMID:23177736 doi:http://dx.doi.org/10.1016/j.molcel.2012.10.015

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