4jal

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==About this Structure==
==About this Structure==
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[[4jal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAL OCA].
+
[[4jal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAL OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:023804755</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:023804755</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Ecoli]]
[[Category: Liu, R J.]]
[[Category: Liu, R J.]]
[[Category: Wang, E D.]]
[[Category: Wang, E D.]]

Revision as of 09:55, 19 March 2014

Template:STRUCTURE 4jal

Contents

Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH

Template:ABSTRACT PUBMED 23804755

Function

[TRML_ECOLI] Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. Recognition of the target requires a pyridine at position 34 and N(6)-(isopentenyl)-2-methylthioadenosine at position 37.[1]

About this Structure

4jal is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

  • Liu RJ, Zhou M, Fang ZP, Wang M, Zhou XL, Wang ED. The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL. Nucleic Acids Res. 2013 Jun 26. PMID:23804755 doi:10.1093/nar/gkt568
  1. ↑ Benitez-Paez A, Villarroya M, Douthwaite S, Gabaldon T, Armengod ME. YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. RNA. 2010 Nov;16(11):2131-43. doi: 10.1261/rna.2245910. Epub 2010 Sep 20. PMID:20855540 doi:10.1261/rna.2245910

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