Isopropylmalate dehydrogenase
From Proteopedia
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[[3h5e]], [[3h5h]], [[3h5j]] - MtIMDH small subunit<br /> | [[3h5e]], [[3h5h]], [[3h5j]] - MtIMDH small subunit<br /> | ||
[[2hcu]] – IMDH small subunit – ''Streptococcus mutans''<br /> | [[2hcu]] – IMDH small subunit – ''Streptococcus mutans''<br /> | ||
| - | [[3q3w]] - IMDH small subunit – ''Campylobacter jejuni''<br /> | + | [[3q3w]], [[3udo]] - IMDH small subunit – ''Campylobacter jejuni''<br /> |
| - | [[ | + | [[3r8w]] - IMDH – ''Arabidopsis thaliana''<br /> |
| - | [[ | + | [[3u1h]] - IMDH – ''Bacillus''<br /> |
| + | [[3vml]] - SoIMDH – ''Shewanella oneidensis/Shewanella benthica''<br /> | ||
'''IMDH binary complexes''' | '''IMDH binary complexes''' | ||
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[[1cnz]] – IMDH + Mn – ''Salmonella typhimurium''<br /> | [[1cnz]] – IMDH + Mn – ''Salmonella typhimurium''<br /> | ||
[[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | [[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | ||
| - | [[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii'' | + | [[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> |
| + | [[4iwh]] - IMDH + Mg – ''Burkholderia thailandensis''<br /> | ||
'''IMDH ternary complexes''' | '''IMDH ternary complexes''' | ||
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[[2ztw]] - TtIMDH + Mg + inhibitor + NAD<BR /> | [[2ztw]] - TtIMDH + Mg + inhibitor + NAD<BR /> | ||
[[2y41]] - TtIMDH + 3IPM + Mn<br /> | [[2y41]] - TtIMDH + 3IPM + Mn<br /> | ||
| + | [[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> | ||
[[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | [[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | ||
[[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca – ''Shewanella oneidensis''<br /> | [[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca – ''Shewanella oneidensis''<br /> | ||
Revision as of 11:35, 19 March 2014
Isopropylmalate dehydrogenase (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses NAD as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation.
3D structures of isopropylmalate dehydrogenase
3-isopropylmalate dehydrogenase
1ipd, 1xaa, 1xab, 1xac, 1xad, 1osi, 1dpz, 1dr0, 1dr8, 2y3z – TtIMDH – Thermus thermophilus
1idm, 1osj, 1wal, 1gc8, 1gc9, 1g2u – TtIMDH (mutant)
2ayq, 1v53 – BcIMDH – Bacillus coagulans
1v5b – BcIMDH (mutant)
1cm7 – IMDH – Escherichia coli
1vlc – IMDH – Thermotoga maritima
1v7l - IMDH – Pyrococcus horikoshii
1w0d, 2g4o - MtIMDH - Mycobacterium tuberculosis
3h5e, 3h5h, 3h5j - MtIMDH small subunit
2hcu – IMDH small subunit – Streptococcus mutans
3q3w, 3udo - IMDH small subunit – Campylobacter jejuni
3r8w - IMDH – Arabidopsis thaliana
3u1h - IMDH – Bacillus
3vml - SoIMDH – Shewanella oneidensis/Shewanella benthica
IMDH binary complexes
1hex – TtIMDH + NAD
2y40 - TtIMDH + Mn
1cnz – IMDH + Mn – Salmonella typhimurium
1wpw - IMDH + Mg – Sulfolobus tokodaii
2pkp - IMDH small subunit + Zn – Methanocaldococcus jannaschii
4iwh - IMDH + Mg – Burkholderia thailandensis
IMDH ternary complexes
2y42 - TtIMDH + Mn + NAD
2ztw - TtIMDH + Mg + inhibitor + NAD
2y41 - TtIMDH + 3IPM + Mn
4f7i - TtIMDH + Mg + 3IPM + NAD
1a05 – IMDH + 3IPM + Mg - Acidithiobacillus ferrooxidans
3vkz, 3vl2, 3vl3, 3vl4, 3vl6, 3vl7 - SoIMDH + 3IPM + Ca – Shewanella oneidensis
3vmj - SoIMDH + 3IPM + Mg
3vmk - IMDH + 3IPM + Mg – Shewanella bethica
2-isopropylmalate dehydrogenase
3fig - MtIMDH (mutant) + Zn
