This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Kdo-8-phosphate synthase
From Proteopedia
| Line 12: | Line 12: | ||
[[2qkf]] – NmKPS + Na – Neisseria meningitides<br /> | [[2qkf]] – NmKPS + Na – Neisseria meningitides<br /> | ||
[[3fyo]] - NmKPS (mutant) + Mn<br /> | [[3fyo]] - NmKPS (mutant) + Mn<br /> | ||
| - | [[3qpy]], [[3qpz]], [[3qq0]], [[3stc]], [[3ste]], [[3stf]] - NmKPS (mutant) + Na | + | [[3qpy]], [[3qpz]], [[3qq0]], [[3stc]], [[3ste]], [[3stf]], [[4jte]], [[4jtf]], [[4jtg]], [[4jth]], [[4jti]], [[4jtj]], [[4jtk]], [[4jtl]] - NmKPS (mutant) + Na<br /> |
| + | [[3sz8]] – BpKPS-2 – ''Burkholderia pseudomallei''<br /> | ||
| + | [[4lu0]] – KPS – ''Pseudomonas aeruginosa''<br /> | ||
==Metallo Kdo8P binary complex== | ==Metallo Kdo8P binary complex== | ||
| Line 25: | Line 27: | ||
[[1fy6]] - AaKPS + A5P + Cd<br /> | [[1fy6]] - AaKPS + A5P + Cd<br /> | ||
[[3e12]] - AaKPS + Kdo-8-P + Cu<br /> | [[3e12]] - AaKPS + Kdo-8-P + Cu<br /> | ||
| - | [[3fyp]] - NmKPS (mutant) + PEP + Mn | + | [[3fyp]] - NmKPS (mutant) + PEP + Mn<br /> |
| + | [[3tmq]] - BpKPS + arabinose-5-phosphate<br /> | ||
==Metallo Kdo8P ternary complex== | ==Metallo Kdo8P ternary complex== | ||
| Line 36: | Line 39: | ||
[[2a2i]] - AaKPS + A5P + PEP + Zn<br /> | [[2a2i]] - AaKPS + A5P + PEP + Zn<br /> | ||
[[1lrq]], [[1t8x]] - AaKPS (mutant) + A5P + PEP + Cd<br /> | [[1lrq]], [[1t8x]] - AaKPS (mutant) + A5P + PEP + Cd<br /> | ||
| + | [[3und]] - BpKPS + arabinose-5-phosphate + PEP<br /> | ||
===Non-metallo Kdo8P=== | ===Non-metallo Kdo8P=== | ||
| Line 41: | Line 45: | ||
[[1d9e]], [[1gg0]], [[1x8f]] – EcKPS <br /> | [[1d9e]], [[1gg0]], [[1x8f]] – EcKPS <br /> | ||
[[1fx6]] - AaKPS <br /> | [[1fx6]] - AaKPS <br /> | ||
| - | [[2nws]] - AaKPS (mutant) <br /> | + | [[2nws]], [[2nx3]] - AaKPS (mutant) <br /> |
[[1o60]] - KPS – Haemophilus influenza<br /> | [[1o60]] - KPS – Haemophilus influenza<br /> | ||
[[3e9a]] - KPS – Vibrio cholera<br /> | [[3e9a]] - KPS – Vibrio cholera<br /> | ||
Revision as of 09:48, 20 March 2014
Kdo-8-phosphate synthase (KPS) catalyzes the formation of the phosphorylated rare sugar Kdo-8-phosphate (Kdo-8-P) from phosphoenolpyruvate (PEP) and D-arabinose-5-phosphate (A5P). KPS is a metal-requiring enzyme. Kdo-8-P is found in cell walls of higher plants and some green algae.
Contents |
3D structures of Kdo-8-phosphate synthase
Metallo Kdo8P
1fxp - AaKPS + Cd – Aquifex aeolicus
1lrn, 1t99 - AaKPS (mutant) + Cd
2qkf – NmKPS + Na – Neisseria meningitides
3fyo - NmKPS (mutant) + Mn
3qpy, 3qpz, 3qq0, 3stc, 3ste, 3stf, 4jte, 4jtf, 4jtg, 4jth, 4jti, 4jtj, 4jtk, 4jtl - NmKPS (mutant) + Na
3sz8 – BpKPS-2 – Burkholderia pseudomallei
4lu0 – KPS – Pseudomonas aeruginosa
Metallo Kdo8P binary complex
1fws – AaKPS + PEP + Cd
3e0i - AaKPS + PEP + Cu
1lro, 1t96 - AaKPS (mutant) + PEP + Cd
1pck - AaKPS + PEP derivative + Cd
1pe1 - AaKPS + phosphoglyceric acid + Cd
2a21 - EcKPS + PEP + Zn - Escherichia coli
1jcx, 1pcw - AaKPS + inhibitor + Cd
1fy6 - AaKPS + A5P + Cd
3e12 - AaKPS + Kdo-8-P + Cu
3fyp - NmKPS (mutant) + PEP + Mn
3tmq - BpKPS + arabinose-5-phosphate
Metallo Kdo8P ternary complex
1fwt - AaKPS + erythrose-4-phosphate + PEP + Cd
1jcy - AaKPS + ribose-5-phosphate + PEP + Cd
1zha - AaKPS (mutant) + ribose-5-phosphate + PEP + Cd
1zji - AaKPS (mutant) + ribose-5-phosphate + phosphoglyceric acid + Cd
1fww - AaKPS + A5P + PEP + Cd
2a2i - AaKPS + A5P + PEP + Zn
1lrq, 1t8x - AaKPS (mutant) + A5P + PEP + Cd
3und - BpKPS + arabinose-5-phosphate + PEP
Non-metallo Kdo8P
1d9e, 1gg0, 1x8f – EcKPS
1fx6 - AaKPS
2nws, 2nx3 - AaKPS (mutant)
1o60 - KPS – Haemophilus influenza
3e9a - KPS – Vibrio cholera
3fs2 - KPS – Brucella melitensis
3qq1, 3stg - NmKPS (mutant)
3t4c, 3tml - KPS – Burkholderia ambifaria
Non-metallo Kdo8P binary complex
2nxi, 1fwn - AaKPS + PEP
2nwr, 2nxh - AaKPS (mutant) + PEP
1g7u, 1q3n - EcKPS + PEP
1phq, 1pl9 - EcKPS + PEP derivative
1phw - EcKPS + A5P derivative
1g7v - EcKPS + inhibitor
1x6u - EcKPS + Kdo-8-P
Non-metallo Kdo8P ternary complex
1fxq - AaKPS + A5P + PEP
2nx1, 2ef9 - AaKPS (mutant) + A5P + PEP
2nxg - AaKPS (mutant) + octanoic acid derivative + A5P + PEP
