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From Proteopedia
(Difference between revisions)
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<StructureSection load='' size='450' side='right' scene='58/580299/Human_monoglyceride_lipase/1' caption='Bovine aconitase showing FeS4 cluster complex with sulfate (PDB code [[1amj]])'> | <StructureSection load='' size='450' side='right' scene='58/580299/Human_monoglyceride_lipase/1' caption='Bovine aconitase showing FeS4 cluster complex with sulfate (PDB code [[1amj]])'> | ||
[[Image:Complete_crystal_structure.png|left|300px|thumb|Crystal Structure of MGL]] | [[Image:Complete_crystal_structure.png|left|300px|thumb|Crystal Structure of MGL]] | ||
| - | ==Background== | + | ==Background== |
| - | + | Monoglyceride lipase is part of the α/β hydrolase family, having a Ser-His-Asp catalytic triad (Celemnte et al. 2012). MGL terminates the signaling of a primary endocannabinoid, 2-AG (Savinainen et al 2010). MGL is able to hydrolyze 2-arachidonoylglycerol into arachidonic acid and glycerol (Bertrand et al. 2010). One of the key features of MGL is the hydrophobic tunnel, which has been suggested to provide a model for drug research. | |
| - | ===Metabolic Role=== | + | |
| + | ===Metabolic Role=== | ||
| + | |||
===Component of Endocannabinoid System=== | ===Component of Endocannabinoid System=== | ||
Revision as of 12:07, 25 March 2014
Monoglyceride Lipase (MGL)
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