Sandbox Reserved 911
From Proteopedia
(Difference between revisions)
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==Hydrolase Information== | ==Hydrolase Information== | ||
| + | Crystal structures of FAAH show that the enzyme is a homodimer in solution, with each subunit having a mass of 63 kD. The protein's <scene name='57/573125/2vya/8'>twisted Beta sheet core</scene> of 11 strands is surrounded by 24 alpha helices. | ||
<scene name='57/573125/2vya/1'>humanized rat FAAH dimer</scene> with <scene name='57/573125/2vya/3'>PF-750 inhibitor</scene> | <scene name='57/573125/2vya/1'>humanized rat FAAH dimer</scene> with <scene name='57/573125/2vya/3'>PF-750 inhibitor</scene> | ||
<scene name='57/573125/2vya/5'>membrane</scene> | <scene name='57/573125/2vya/5'>membrane</scene> | ||
| - | |||
| - | <scene name='57/573125/2vya/8'>twisted Beta sheet core</scene> of 11 strands surrounded by 24 alpha helices | ||
<scene name='57/573125/2vya/7'>helix-turn-helix motif</scene> alpha helices 18 and 19 form a membrane binding cap | <scene name='57/573125/2vya/7'>helix-turn-helix motif</scene> alpha helices 18 and 19 form a membrane binding cap | ||
Revision as of 12:33, 25 March 2014
| This Sandbox is Reserved from Jan 06, 2014, through Aug 22, 2014 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 911 through Sandbox Reserved 922. |
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Applications
The human nervous system has several types of chemical messengers, including amino acids, lipids, peptide hormones, and monoamines. FAAH primarily degrades anandamide (AEA), a naturally-occurring signaling lipid that functions in the brain. AEA brings pain relief to the body. Inhibiting FAAH would likely sustain AEA signaling, leading to prolonged pain relief and decreased inflammation.
