4kar

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-	'''Unreleased structure'''	+	{{STRUCTURE_4kar| PDB=4kar | SCENE= }}
		+	===Crystal structure of FDTS (TM0449) mutant (H53D) with FAD===
		+	{{ABSTRACT_PUBMED_24563811}}
-	The entry 4kar is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/THYX_THEMA THYX_THEMA]] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.
-	Authors: Mathews, I.I.	+	==About this Structure==
		+	[[4kar]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KAR OCA].
-	Description: Crystal structure of FDTS (TM0449) mutant (H53D) with FAD	+	==Reference==
		+	<ref group="xtra">PMID:024563811</ref><references group="xtra"/><references/>
		+	[[Category: Mathews, I I.]]
		+	[[Category: Convertion of dump to dtmp using tetrahydrofolate]]
		+	[[Category: Fad]]
		+	[[Category: Fdt]]
		+	[[Category: H53d mutant]]
		+	[[Category: Novel fdts fold]]
		+	[[Category: Thyx]]
		+	[[Category: Transferase]]

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Revision as of 09:20, 26 March 2014

Template:STRUCTURE 4kar

Contents 1 Crystal structure of FDTS (TM0449) mutant (H53D) with FAD 2 Function 3 About this Structure 4 Reference

Crystal structure of FDTS (TM0449) mutant (H53D) with FAD

Template:ABSTRACT PUBMED 24563811

Function

[THYX_THEMA] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.

About this Structure

4kar is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

• Mathews II. Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef. 2013 Apr 20;Suppl 12:004. PMID:24563811 doi:http://dx.doi.org/10.4172/2157-2526.S12-004