3whk
From Proteopedia
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| - | + | {{STRUCTURE_3whk| PDB=3whk | SCENE= }} | |
| + | ===Crystal structure of PAN-Rpt5C chimera=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/PAN_PYRFU PAN_PYRFU]] ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[3whk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHK OCA]. | |
| - | + | [[Category: Hiromoto, T.]] | |
| + | [[Category: Kato, K.]] | ||
| + | [[Category: Mizushima, T.]] | ||
| + | [[Category: Saeki, Y.]] | ||
| + | [[Category: Satoh, T.]] | ||
| + | [[Category: Tanaka, K.]] | ||
| + | [[Category: Uekusa, Y.]] | ||
| + | [[Category: Wang, Y H.]] | ||
| + | [[Category: Yagi, H.]] | ||
| + | [[Category: Yagi-Utsumi, M.]] | ||
| + | [[Category: Yoshihara, H.]] | ||
| + | [[Category: Atp binding]] | ||
| + | [[Category: Four-helix bundle]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Proteasome atpase subunit]] | ||
Revision as of 09:29, 26 March 2014
Crystal structure of PAN-Rpt5C chimera
Function
[PAN_PYRFU] ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates (By similarity).
About this Structure
3whk is a 8 chain structure. Full crystallographic information is available from OCA.
