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4hnx

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4hnx| PDB=4hnx | SCENE= }}
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===The NatA Acetyltransferase Complex Bound To ppGpp===
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The entry 4hnx is ON HOLD until Mar 26 2015
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==Function==
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[[http://www.uniprot.org/uniprot/NAT1_YEAST NAT1_YEAST]] Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.<ref>PMID:1600941</ref> <ref>PMID:14517307</ref> [[http://www.uniprot.org/uniprot/ARD1_YEAST ARD1_YEAST]] Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.<ref>PMID:1600941</ref>
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Authors: Neubauer, J.L., Immormino, R.M., Dollins, D.E., Endo-Streeter, S.T., Pemble IV, C.W., York, J.D.
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==About this Structure==
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[[4hnx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNX OCA].
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Description:
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Peptide alpha-N-acetyltransferase]]
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[[Category: Dollins, D E.]]
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[[Category: Endo-Streeter, S T.]]
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[[Category: IV, C W.Pemble.]]
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[[Category: Immormino, R M.]]
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[[Category: Neubauer, J L.]]
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[[Category: York, J D.]]
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[[Category: Gnat/tpr]]
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[[Category: N-terminal acetyltransferase]]
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[[Category: Ppgpp]]
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[[Category: Transferase]]

Revision as of 09:31, 26 March 2014

Template:STRUCTURE 4hnx

Contents

The NatA Acetyltransferase Complex Bound To ppGpp

Function

[NAT1_YEAST] Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation.[1] [2] [ARD1_YEAST] Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover.[3]

About this Structure

4hnx is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Park EC, Szostak JW. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 1992 Jun;11(6):2087-93. PMID:1600941
  2. ↑ Gautschi M, Just S, Mun A, Ross S, Rucknagel P, Dubaquie Y, Ehrenhofer-Murray A, Rospert S. The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol Cell Biol. 2003 Oct;23(20):7403-14. PMID:14517307
  3. ↑ Park EC, Szostak JW. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 1992 Jun;11(6):2087-93. PMID:1600941

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