4jqc

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'''Unreleased structure'''
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{{STRUCTURE_4jqc| PDB=4jqc | SCENE= }}
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===Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AFN-1252===
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The entry 4jqc is ON HOLD until Mar 20 2015
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==Function==
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[[http://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI]] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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Authors: Subramanya, H., Rao, K.N., Anirudha, L.
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==About this Structure==
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[[4jqc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQC OCA].
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Description: Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AFN-1252
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Anirudha, L.]]
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[[Category: Rao, K N.]]
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[[Category: Subramanya, H.]]
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[[Category: Enoyl reductase]]
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[[Category: Fabi]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 09:32, 26 March 2014

Template:STRUCTURE 4jqc

Contents

Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AFN-1252

Function

[FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.[1] [2] [3]

About this Structure

4jqc is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Bergler H, Wallner P, Ebeling A, Leitinger B, Fuchsbichler S, Aschauer H, Kollenz G, Hogenauer G, Turnowsky F. Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli. J Biol Chem. 1994 Feb 25;269(8):5493-6. PMID:8119879
  2. ↑ Heath RJ, Rock CO. Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. J Biol Chem. 1995 Nov 3;270(44):26538-42. PMID:7592873
  3. ↑ Lin S, Hanson RE, Cronan JE. Biotin synthesis begins by hijacking the fatty acid synthetic pathway. Nat Chem Biol. 2010 Sep;6(9):682-8. doi: 10.1038/nchembio.420. Epub 2010 Aug 8. PMID:20693992 doi:http://dx.doi.org/10.1038/nchembio.420

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