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[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]]
[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]]
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Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] represent a class of esterases within the hydrolase class that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. <ref name="Nam">PMID:19089974</ref>
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Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] represent a class of esterases within the hydrolase class that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. <ref name="Nam">PMID:19089974</ref>
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==Structure and Biology of Hormone-Sensitive Lipase==
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==Structure of Hormone-Sensitive Lipase==
<StructureSection load='3DNM' size='350' frame='true' align='right' caption='Hormone-Sensitive Lipase from [[3dnm]]' scene='58/580297/3dnm_cartoon/2' >
<StructureSection load='3DNM' size='350' frame='true' align='right' caption='Hormone-Sensitive Lipase from [[3dnm]]' scene='58/580297/3dnm_cartoon/2' >

Revision as of 22:58, 26 March 2014

Contents

Introduction to Hormone-Sensitive Lipase

Image:HPL Movie0006.png
Hormone-Sensitive Lipase

Hormone-sensitive lipases represent a class of esterases within the hydrolase class that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various catecholamines and inhibited by insulin. [1]


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Structure of Hormone-Sensitive Lipase

Hormone-Sensitive Lipase from 3dnm

Drag the structure with the mouse to rotate





Inhibition of Hormone-Sensitive Lipase

Medical Relevance of Hormone-Sensitive Lipase

Additional Pages about Hormone-Sensitive Lipase

References

  1. Nam KH, Kim MY, Kim SJ, Priyadarshi A, Kwon ST, Koo BS, Yoon SH, Hwang KY. Structural and functional analysis of a novel hormone-sensitive lipase from a metagenome library. Proteins. 2009 Mar;74(4):1036-40. PMID:19089974 doi:http://dx.doi.org/10.1002/prot.22313
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