3esk

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[[Image:3esk.png|left|200px]]
 
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{{STRUCTURE_3esk| PDB=3esk | SCENE= }}
{{STRUCTURE_3esk| PDB=3esk | SCENE= }}
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===Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand===
===Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand===
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{{ABSTRACT_PUBMED_19586912}}
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{{ABSTRACT_PUBMED_19586912}}
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==Function==
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[[http://www.uniprot.org/uniprot/STIP1_HUMAN STIP1_HUMAN]] Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). [[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>
==About this Structure==
==About this Structure==
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[[3esk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ESK OCA].
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[[3esk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ESK OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:019586912</ref><references group="xtra"/>
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<ref group="xtra">PMID:019586912</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Kajander, T.]]
[[Category: Kajander, T.]]
[[Category: Regan, L.]]
[[Category: Regan, L.]]

Revision as of 07:04, 2 April 2014

Template:STRUCTURE 3esk

Contents

Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand

Template:ABSTRACT PUBMED 19586912

Function

[STIP1_HUMAN] Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). [HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.[1]

About this Structure

3esk is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Kajander T, Sachs JN, Goldman A, Regan L. Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. J Biol Chem. 2009 Sep 11;284(37):25364-74. Epub 2009 Jul 7. PMID:19586912 doi:10.1074/jbc.M109.033894
  1. ↑ Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34. PMID:10722728

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