4hxx
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | [[4hxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4hxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HXX OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[Aminopeptidase|Aminopeptidase]] | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023507151</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Methionyl aminopeptidase]] | [[Category: Methionyl aminopeptidase]] | ||
[[Category: Amzel, L M.]] | [[Category: Amzel, L M.]] | ||
Revision as of 07:31, 2 April 2014
Contents |
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Template:ABSTRACT PUBMED 23507151
Function
[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.[1] [2]
About this Structure
4hxx is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Zhang P, Yang X, Zhang F, Gabelli SB, Wang R, Zhang Y, Bhat S, Chen X, Furlani M, Amzel LM, Liu JO, Ma D. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem. 2013 Feb 21. pii: S0968-0896(13)00147-8. doi:, 10.1016/j.bmc.2013.02.023. PMID:23507151 doi:10.1016/j.bmc.2013.02.023
- ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
- ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291
